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Characterization of Monoclonal Antibodies and ADCs using a Benchtop Orbitrap Mass Spectrometer

Reputable Mentor II
Reputable Mentor II
Zheng X.
ASMS 2015 Poster Note 64397
Purpose: To characterize mAbs and ADCs with high resolution Orbitrap mass spectrometer. Methods: Coupling High Performance Liquid Chromatography with high resolution Orbitrap mass spectrometer (HPLC-MS) enables accurate mass measurement of mAb, ADCs, and peptide mapping experiments. Results: For Herceptin, 7 major glycoforms were detected; 100% sequence coverage of the ADC sample was achieved, and the modifications, including the drug-conjugated site information were determined; K42 and K103 were 100% modified by DM1 with good reproducibility were observed.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 09:12 AM
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