Analysis of pharmaceuticals, steroids and antibiotics using UHPLC- Orbitrap mass spectrometry with enhanced sensitivity, selectivity and minimal matrix effects

[Orbitrap_SciLib]

Thach S, Yang p, Yang C, Chang J, Akervik K, Bromirski M, Ghosh D.
EPRW 2012 Poster
Ultrahigh pressure liquid chromatography/tandem mass (UHPLC-MS/MS) and UHPLC-orbitrap analytical methods have been applied to the analysis of pharmaceuticals and personal care products (PPCPs) in environmental sample matrices. Special emphasis was made on difficulties associated with matrix effects in the electrospray ionization source (ESI) and strategies that can be used to alleviate this phenomenon utilizing the unique ability of a new orbitrap mass spectrometer.


Thermo Fisher Scientific