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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II
Pashmi J, Li S, Kou B, Casteel D.
Scientific Poster
Purpose: To study the dynamics of the PKGIβ regulatory domain when bound to saturating amounts (1mM) of cGMP or cAMP. Methods: HDX-MS performed on the PKGIβ peptides in presence of cGMP or cAMP Results: New instrumentation provided higher coverage (326 peptides vs. 117) using much less protein (3 μg vs. 50 μg) compared to previously acquired results. The increased coverage includes H/DX exchange information for the heretofore unknown leucine zipper region.


Thermo Fisher Scientific
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Last update:
‎10-15-2021 09:09 AM
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