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Analysis of Synthetic Cannabinoids (Spice) in Urine Utilizing HRAM

Reputable Mentor II
Reputable Mentor II
Van Natta K.
Slide Presentation
• Newly scheduled synthetic cannabinoids need to be analyzed. • Look for W- and (W-1)-alkyl-OH and alkyl-COOH in urine • Analytical challenges due to identical fragments, isobaric nominal masses and isomeric metabolites. • Chromatography must be used to separate isomers • Equivalent detector response for W /(W-1) isomers • Faster analysis by HRAM when W and (W-1) don’t need to be separated • -OH and –COOH respond differently to hydrolysis conditions • Good precision, accuracy, linearity, carryover and no matrix effects

Thermo Fisher Scientific
Version history
Last update:
‎10-15-2021 08:36 AM
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