Viner R, Zhang T, Peterman S, Zabrouskov V.
Scientific Poster
Comprehensive, accurate identification of proteins in complex sample mixtures is an
important fundamental capability for any proteomics research laboratory. Technology
advancements in both hardware and software continue to expand and refine our view of any proteomic system in terms of protein identities and their posttranslational
modifications (PTMs). It has been suggested that the very recent ability to routinely
obtain accurate mass measurements (<5 ppm RMS) on precursor and MS/MS fragment
ions in proteomic experiments should lead to unprecedented accuracy in the ability to
identify and characterize proteins.1 This paper compares alternative approaches to this
challenging application using two high performance platforms for proteomics: a QqTOF
instrument (QSTAR Elite from Applied Biosystems) and a hybrid linear ion trap-orbitrap
instrument (LTQ Orbitrap XL from Thermo Fisher Scientific).
Thermo Fisher Scientific
United States
