on 05-01-201210:35 AM - edited on 10-15-202105:47 AM by AnalyteGuru
May 11, 2009
Thermo Fisher Scientific Inc., the world leader in serving science, today launched two new mass spectrometers, the Thermo Scientific LTQ Velos and LTQ Orbitrap Velos systems at ACHEMA 2009 in Frankfurt, Germany, from May 11-15.
The LTQ Velos features a new dual pressure trap design and API source, making it the world’s fastest and most-sensitive ion trap mass spectrometer. The unique dual pressure trap technology features two discrete pressure regions that allow the decoupling of ion manipulation and detection. This enables the utilization of optimal pressures during analysis, increasing both scan speed and resolution.
The LTQ Orbitrap Velos combines the industry-leading Orbitrap mass analyzer, a new Higher-Energy Collisional Dissociation (HCD) cell and dual pressure trap technology to routinely deliver ultra-high resolution and accurate mass data.
The speed of the LTQ Velos-based mass spectrometers is ideal for coupling to U-HPLC systems, enabling researchers to identify more compounds in less time. The Thermo Scientific LTQ Velos and LTQ Orbitrap Velos will be on display on booth B1-C11, Hall 6.1 at ACHEMA 2009 in Frankfurt, Germany, from May 11 – 15.
"The new dual pressure trap and S-Lens API interface combine to deliver increased sensitivity, improved ion transmission, and more efficient trapping and fragmentation of ions," said Iain Mylchreest, vice president of mass spectrometry for Thermo Fisher Scientific. "These major enhancements result in the fastest and most sensitive ion trap and Orbitrap mass spectrometers for any application involving complex mixtures."
The LTQ Velos – The reinvention of ion trap technology
The outstanding data quality and sensitivity of the LTQ Velos make it ideal for the analysis of complex mixtures, such as the identification of low level proteins and structural elucidation of metabolites in biological matrices.
For proteomics applications, the improvements in speed and sensitivity provide greater coverage in the analysis of complex peptide mixtures, increasing the confidence of protein identification at low sample levels. The multiple fragmentation techniques available on the LTQ Velos enable more confident sequence assignment and post-translational modification (PTM) identification. Faster scan rates also reduce cycle times by up to 50 percent, doubling the number of proteins and peptides identified.
For metabolism applications, the dual pressure trap technology increases fragmentation efficiencies, resulting in faster, more confident structural elucidation. The improved speed and sensitivity combines with MSn capabilities, maximizing throughput while maintaining the superior data quality required for the identification and quantitation of multiple co-eluting compounds.
The LTQ Velos can be upgraded to the LTQ Orbitrap Velos, allowing laboratories to extend their initial investment to include accurate mass and ultra-high resolution capabilities with no compromise to sensitivity and speed of analysis.
The LTQ Orbitrap Velos – Powered by Orbitrap technology
The LTQ Orbitrap Velos combines the proven mass accuracy and ultra-high resolution of the Orbitrap mass analyzer, with the increased sensitivity and improved cycle time of the LTQ Velos to deliver high performance hybrid mass spectrometry.
The high mass accuracy of the LTQ Orbitrap Velos increases the speed and confidence of protein identification in complex samples by minimizing false positives. The ultra-high resolution delivers certainty in analytical results by enabling molecular weight determination for intact proteins and in-depth analysis of isobaric species. For proteomics researchers, these capabilities enable the identification of more proteins with increased sequence coverage and higher confidence.
The new HCD cell in the LTQ Orbitrap Velos is more efficient, resulting in improved quantitation of isobarically-labeled peptides, such as applications requiring tandem mass tags (TMT). Electron Transfer Dissociation (ETD) generates complementary information for highly sensitive PTM analyses and de novo sequencing.
For metabolism applications, the LTQ Orbitrap Velos provides researchers with high-resolution accurate mass data for more confident structural elucidation.
With these new features, Thermo Scientific LTQ Orbitrap technology remains the most comprehensive structural identification mass spectrometry instrument and the platform of choice for the most confident protein and metabolite identification, characterization and quantitation.