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A simplified approach to fast and accurate, high throughput targeted MS2 quantitation using internal standards

Reputable Mentor II
Reputable Mentor II
Eliuk S, Huguet R, Blank M, Zabrouskov V, McAlister G.
ASMS 2016 Poster
Purpose: To develop a simplified approach to fast and accurate, high-throughput targeted MS2 quantitation. Methods: A QuanDirectTM method was developed for the analysis of complex, peptide-containing samples, wherein the sample is spiked with heavy labeled versions of the endogenous peptide of interest. Results: A method is provided that obtains impressive sensitivity and selectivity, and is able to target a large number of precursors in an extremely complex mixture, all while being easy to set up and execute.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 06:09 AM
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