A Study of Apolipoprotein E4 Oligomerization by H/DX and Electron-Transfer Dissociation

[steve-day]

To elucidate the regions of Apo E4 lipoprotein responsible for oligomerization by comparing the wild-type protein (WT) and monomeric-mutant (MM) (F257A; W264R; L279Q; V287E), using H/D amide exchange (H/DX) coupled with Electron-Transfer Dissociation (ETD) mass spectrometry.