A Novel Instrumental Strategy for Parallel Reaction Monitoring of Intact Proteins with an Orbitrap Analyzer

[Orbitrap_SciLib]

Belov M, Grinfeld D, Compton P, Kelleher N, Makarov A.
ASMS 2015 Poster Note 64494
Purpose: Increase sensitivity of analysis by concurrent mass selection of multiple species Methods: Time-of-flight mass selector is used in place of mass selection quadrupole filter in a quadrupole-Orbitrap hybrid Mass Spectrometer Results: Viability of the concept is explored using simulation and initial experiments


Spectroglyph LLC, Thermo Fisher Scientific, and Northwestern University