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A Modified Orbitrap Tribrid Mass Spectrometer with Real Time Search and Advanced Spectral Processing Enhances Multiplexed Proteome Coverage and Quantification Accuracy

Reputable Mentor II
Reputable Mentor II
Aaron M. Robitaille 1, Romain Huguet 1, Derek J. Bailey 1, Graeme McAlister 1, Arne Kreutzmann 2, Daniel Mourad 2, Daniel Lopez-Ferrer 1, Andreas Huhmer 1, Vlad Zabrouskov 1

Isobaric tagging strategies using Thermo Scientific™ Tandem Mass Tags™ (TMT™) are powerful tools for studying how proteins interact and function in biological systems. Up to 11 samples can be multiplexing in a single high-resolution LC/MS experiment to enable state-of-the-art quantitative analysis of peptide and protein abundance. Here we evaluate the benefits of the Thermo Scientific™ Orbitrap Eclipse ™ Tribrid ™ mass spectrometer including real time search capabilities, advanced spectral processing algorithms, and modified hardware to enhance TMT quantification accuracy and proteome coverage.

1 Thermo Fisher Scientific, 355 River Oaks Pkwy, San Jose, CA 95134. 2 Thermo Fisher Scientific Hanna-Kunath-Straße 11, 28199 Bremen, Germany
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Last update:
‎10-15-2021 10:53 AM
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