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A High Resolution Accurate Mass Approach for the Quantitation of Buprenorphine and Paroxetine in Rat Plasma

Reputable Mentor II
Reputable Mentor II
Peake D, Kiyonami R, Yokoi Y, Fukamachi Y, Huang Y.
ASMS 2015 Poster Note 64485
Purpose: To demonstrate a High Resolution Accurate Mass (HRAM) approach for the quantitation of Buprenorphine and Paroxetine in the presence of protein precipitated rat plasma. Methods: Sample analysis was performed using Single Ion Monitoring (SIM) with generic mass spectrometer source conditions and chromatographic separation utilizing ultra high performance chromatography (UHPLC). Results: Sample analysis demonstrated a lower limit of quantitation (LOQ) of 10pg/mL for both analytes, a linear signal response of more than four orders of magnitude, a coefficient of variance of less than ten percent for all replicate injections.

Thermo Fisher Scientific and Mitsui Knowledge Industry
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Last update:
‎10-15-2021 11:04 AM
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