on 09-29-201410:18 AM - edited on 10-15-202111:27 AM by AnalyteGuru
Le DH, Takenaka Y, Hamada N, Miyawaki H, Tanahashi T. Chem Pharm Bull (Tokyo). 2013;61(3):358-62. Epub 2012 Dec 20. Spore-derived mycobionts of the crustose lichen Graphis vestitoides collected in Vietnam were cultivated on a malt-yeast extract medium supplemented with 10% sucrose. The investigation of their metabolites resulted in isolation of a novel 14-membered macrolide and a new isocoumarin, together with five known isocoumarin derivatives. Their structures were determined by spectroscopic and chemical means. This is the first instance of isolation of a 14-membered macrolide from a lichen mycobiont.