on 03-06-2023 09:53 AM - edited on 03-13-2023 04:41 PM by GeorgeTFS
Ultrasensitive MS-based proteomics has seen remarkable breakthroughs in recent years. Improvements at different stages in the proteomics workflow have pushed sensitivity to a level that now allows scientists to successfully identify and quantify more than 1,000 proteins from a single mammalian cell.
Optimized sample handling, maximum separation efficiency at low nanoLC flow rates and high-resolution mass spectrometry are key technologies to achieve maximum sensitivity. Increase in sampling depth and proteome coverage can be accomplished by rapid advances in mass spectrometer technology. However, appropriate selection of the nanoLC column is critical to provide MS instruments with peptides separation at the highest possible resolution.
Thermo Scientific™ μPAC™ (micro Pillar Array Column) technology is unique — built by precise micromachining chromatographic separation beds from silicon. This approach brings three critical and unique characteristics:
The column can be operated at moderate LC pump pressures up to 450 bar over a wide range of flow rates:
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