Mass spec for RNA characterization

[Thennavan]

Is it possible to detect RNA modification such as pseudouridilylation, and phosphorylation using "Orbitrap Fusion Lumos Tribrid Mass Spectrometer"? Or do need any additional support to accomplish this task?

[Molly_I2]

@Thennavan -welcome to the AnalyteGuru online community. I am seeking support from the team and will ask them to converse with you here! We appreciate your willingness to ask a question! @MartinJech and @Flying_Ions  please help me welcome Thennavan!

[Molly_I2]

@Thennavan I wanted to connect you with @Min_Du_Thermo - She will be able to provide some insight. She is traveling this week, so will reach out soon with more information on her recommendations on the topic. 

[Min_Du_Thermo]

Hi, Thennavan,

Thanks for reaching out and asking the question. The data collected from Orbitrap MS instruments, including Orbitrap Fusin Lumos can be processed by Biopharma Finder software to identify RNA modifications. Please check out the Biopharma Finder website: BioPharma Finder Software | Thermo Fisher Scientific - US. You can download the trial version of the Biopharma Finder software with training dataset to ty it out. If you have more questions, please feel free to reach out.

Best,

Min Du

[Molly_I2]

@Thennavan - Please let us know if you question has been answer by "accepting as solution", or let us know if additional information is still needed for your inquiry.