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NaOH vs KOH

SeanA
Involved Contributor
Involved Contributor

When you buy a new CarboPac column it always comes with a Quality Assurance Report (QAR).  So we can always test the columns following the procedure in the QAR to see if the column still meets the specifications.  However sometimes the QAR is conducted using sodium hydroxide, while for other columns it is conduced with potassium hydroxide.  Is there an influence on column performance using KOH vs NaOH ?  If I test the column using NaOH instead of KOH would I expect the same results, or would I expect that retention times are shifted (and if so, in what direction ?).

 

 

1 REPLY 1

The_Ion_Lady
Team TFS
Team TFS

That is a good point!

There is a Technical note 70671 that mentions the equivalency chromatographically of KOH vs NaOH upto 100mM:

TN70671: Carbohydrate analysis by HPAE-PAD 

I too use QAR to check if my columns are OK before I do method development, it is so important! 😊

 

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