In the last few years, various authors have predicted that some or most triple-quadrupole mass spectrometry (MS) systems would be replaced by high-resolution (HRMS) instruments, particularly as we see more and more demonstrations of the capability of HRMS instruments to perform sensitive and reliable quantification of a large variety of analytes in HR-full scan mode. In this webinar Dr. Bertrand Rochat of Faculté de Biologie et de Médecine of the Centre Hospitalier Universitraire Vaudois (CHUV) at Lausanne will discuss the use of new, affordable HRMS instruments in quantitative clinical research analyses, demonstrating the sensitivity and selectivity of these instruments for this work. Examples of clinical research quantification work in HR full scan or MS/MS mode will be presented and compared with results from triple quadrupole-MS.