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Identifying & quantifying MHC antigens with immunopeptidomics webinar
Monday, May 9, 2022
REGISTER HERE   Peptides bound to class I major histocompatibility complexes (MHC) play a critical role in immune cell recognition and can trigger an immune response in many disease contexts including cancer, infectious disease, and autoimmunity. The collection of peptide MHCs (pMHCs) present on the cell surface, commonly referred to as the “immunopeptidome,” serves as a rich source of disease-specific targets. Methods to identify the immunopeptidome rely heavily on mass spectrometry to identify thousands of unique pMHC complexes in a relatively unbiased manner. However, analysing MHC MS datasets pose unique challenges over traditional proteomics datasets due to their non-tryptic nature.   Here we leverage deep learning via the Thermo Scientific INFERYS Rescoring workflow in Thermo Scientific Proteome Discoverer software to enhance the depth of pMHC identifications from MS analysis, increasing the number of tumor-associated antigens identified in in vitro samples and human tumor specimens. We further apply this analysis framework in conjunction with quantitative immunopeptidomics methods to identify tumor antigens that selectively increase in presentation in response to drug treatment and develop therapeutic strategies to exploit these treatment-modulated antigens as targets for immunotherapy.   Learn: • How to use immunopeptidomics to study antigen presentation of MHC molecules • Understand how artificial intelligence helps dig deeper into immunopeptidomics mass spectrometry data to identify tumor antigens • Understand how implementing quantitative mass spectrometry-based approaches can identify treatment-modulated tumor antigens as targets for immunotherapy   REGISTER HERE   Speaker: Dr. Lauren Stopfer Lauren earned a B.S. from the University of Wisconsin-Madison and Ph.D. from the Massachusetts Institute of Technology studying phosphoproteomics, immunopeptidomics, and systems biology. She is currently a scientist on the Proteomics team at BioNTech US, where she focuses on applying proteomics and immunopeptidomics methodologies to oncology and infectious disease applications.
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Toward A Next-Generation MAM: An Evaluation of the Orbitrap Exploris MX Mass Detector Webinar
Wednesday, May 25, 2022
  In the development of biotherapeutics, a thorough understanding of a molecule’s product quality attributes (PQAs), and their effect on various structure-function relationships and long-term stability, is essential for ensuring the safety and efficacy of the product. At present, numerous routine chromatographic and electrophoretic assays are used to characterize and monitor individual PQAs. However, execution of multiple routine methods for batch release, stability time-points, and process/formulation development support becomes time and resource intensive, and often provides an indirect measure of biologically relevant PQAs. Introduced in 2015, the multi-attribute method (MAM), based on LC-MS peptide mapping and automation principles, provides simultaneous and site-specific detection, identification, quantitation, and quality control (monitoring) of PQAs.   A dedicated Pfizer team has been regularly employing MAM on an in-house MAM platform to support biotherapeutic process and product development. In parallel, this team has continually explored and implemented improvements in the Pfizer MAM platform, including sample preparation and data processing automation, to move toward the next generation of MAM. Recently, a pre-commercial demo model of the new Thermo Scientific Orbitrap Exploris MX mass detector was evaluated in-house by the Pfizer MAM team. Here, the results of the evaluation and an assessment of the Orbitrap Exploris MX mass detector’s suitability as a next generation MAM instrument are presented.   Learn: Pfizer MAM platform milestones for characterization and routine monitoring Automation of sample handling and data processing and reporting Evaluation and optimization of the Orbitrap Exploris MX mass detector for MAM REGISTER HERE
RAFA - 10th International Symposium on Recent Advances in Food Analysis
Tuesday, September 6, 2022
Prague, Czechia
Safeguarding food safety—today and tomorrow We’re always looking ahead to help you meet the increasing analytical food and beverage testing demands— in your timeframe, and with the high degree of accuracy your consumers and clients expect. Our broad range of innovative chromatography and mass spectrometry instruments, data management and analysis software, sample preparation and separation consumables and general laboratory products will help you achieve your food safety analysis goals. We offer complete end-to-end food testing solutions and educational resources so that you can keep your focus where it should be—delivering safe, high-quality food products. Discover how you can advance and enhance your food safety workflows. Register now to join us at our seminar presentations during RAFA 2022 in September to learn more about the latest instrument developments and applications in food science.   Sep 7, 2022 (13:30-14:15)  Implementing new GC-MS and LC-MS technologies to stay ahead with your food safety analysis from pesticides to PFAS and microplastics   Sep 8, 2022 (13:30-14:15)  Elemental and isotopic analysis: solutions for food authenticity, quality and safety   Sep 8, 2022 (14.45 - 15:30)  Ways to master your pooling testing approach for food pathogen testing   Reserve your seat at:https://www.thermofisher.com/it/en/home/about-us/events/industrial/rafa.html  
Live Webinar: New Developments in Mass Spectrometry-based Single-cell Proteomics
Tuesday, September 27, 2022
  REGISTER HERE The analysis of single-cell proteomes has recently become a viable complement to transcriptomics and genomics studies, as proteins are the main driver of cellular functionality and mRNA levels are often an unreliable proxy of such. Both multiplexed and label-free mass spectrometry-based approaches with single-cell resolution have attributed surprising heterogeneity to cell populations believed to be homogenous. Even though specialized experimental designs and instrumentation have demonstrated remarkable advances, the efficient sample preparation of single cells still lags behind.   In this live webinar, learn how Karl Mechtler has developed an end-to-end workflow to efficiently prepare and analyze samples for single-cell proteomics by mass spectrometry. A cellenONE® proteoCHIP sample preparation device, coupled to Thermo Scientific Orbitrap mass spectrometers, comprises a single-cell proteomics workflow solution with surprising sensitivity and throughput.   Attend this webinar to learn how to: Identify key challenges and solutions for single-cell proteomics experiments Understand an end-to-end workflow for single-cell proteomics sample preparation and analysis Learn how mass spectrometry approaches can be applied to single-cell proteomics REGISTER HERE    
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