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LC-MS
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6 attendees
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MSACL
Tuesday, April 5, 2022
Monterey Conference Center, 1 Portola Plaza, Monterey, CA 93940, USA
Thermo Fisher Scientific is a key partner in the success of the clinical mass spectrometry community, as well as a steadfast contributor to MSACL Educational Grants, Scholarships, mentorship programs and the MSACL Connect platform. Check out the technical program for workshops, short courses, and posters! https://lnkd.in/gb9eYTzd April 5-8 Monterey, California https://www.msacl.org/index.php
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Clinical Research
LC-MS
Mass Spectrometry
Orbitrap
Symposium
Trade Show
6 attendees
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1 attendees
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Identifying & quantifying MHC antigens with immunopeptidomics webinar
Monday, May 9, 2022
REGISTER HERE Peptides bound to class I major histocompatibility complexes (MHC) play a critical role in immune cell recognition and can trigger an immune response in many disease contexts including cancer, infectious disease, and autoimmunity. The collection of peptide MHCs (pMHCs) present on the cell surface, commonly referred to as the “immunopeptidome,” serves as a rich source of disease-specific targets. Methods to identify the immunopeptidome rely heavily on mass spectrometry to identify thousands of unique pMHC complexes in a relatively unbiased manner. However, analysing MHC MS datasets pose unique challenges over traditional proteomics datasets due to their non-tryptic nature. Here we leverage deep learning via the Thermo Scientific INFERYS Rescoring workflow in Thermo Scientific Proteome Discoverer software to enhance the depth of pMHC identifications from MS analysis, increasing the number of tumor-associated antigens identified in in vitro samples and human tumor specimens. We further apply this analysis framework in conjunction with quantitative immunopeptidomics methods to identify tumor antigens that selectively increase in presentation in response to drug treatment and develop therapeutic strategies to exploit these treatment-modulated antigens as targets for immunotherapy. Learn: • How to use immunopeptidomics to study antigen presentation of MHC molecules • Understand how artificial intelligence helps dig deeper into immunopeptidomics mass spectrometry data to identify tumor antigens • Understand how implementing quantitative mass spectrometry-based approaches can identify treatment-modulated tumor antigens as targets for immunotherapy REGISTER HERE Speaker: Dr. Lauren Stopfer Lauren earned a B.S. from the University of Wisconsin-Madison and Ph.D. from the Massachusetts Institute of Technology studying phosphoproteomics, immunopeptidomics, and systems biology. She is currently a scientist on the Proteomics team at BioNTech US, where she focuses on applying proteomics and immunopeptidomics methodologies to oncology and infectious disease applications.
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LC-MS
Mass Spectrometry
Proteomics
1 attendees
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4 attendees
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Free Forensic Toxicology On-line Symposium
Monday, May 16, 2022
The Current Trends Symposium Series is organized by The Center for Forensic Science Research and Education. Over the past 5 years, the symposium has gained a reputation for creating a sense of community for forensic practitioners across the globe while disseminating timely and impactful information from recognized experts in their respective disciplines. There is no registration fee for this event! Thermo Fisher Scientific is a sponsor and will be hosting a workshop. We hope to see you there! https://www.cfsre.org/education/continuing-professional-education/online-live-education/current-trends-in-forensic-toxicology-2022 Speaking behalf of Thermo: Rachel Marvin, Ph.D., Forensic Chemist II – North Carolina Office of the Chief Medical Examiner Kristine Van Natta, Marketing Applications Specialist, Thermo Fisher Scientific
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Clinical Research
LC-MS
Symposium
4 attendees
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1 attendees
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Toward A Next-Generation MAM: An Evaluation of the Orbitrap Exploris MX Mass Detector Webinar
Wednesday, May 25, 2022
In the development of biotherapeutics, a thorough understanding of a molecule’s product quality attributes (PQAs), and their effect on various structure-function relationships and long-term stability, is essential for ensuring the safety and efficacy of the product. At present, numerous routine chromatographic and electrophoretic assays are used to characterize and monitor individual PQAs. However, execution of multiple routine methods for batch release, stability time-points, and process/formulation development support becomes time and resource intensive, and often provides an indirect measure of biologically relevant PQAs. Introduced in 2015, the multi-attribute method (MAM), based on LC-MS peptide mapping and automation principles, provides simultaneous and site-specific detection, identification, quantitation, and quality control (monitoring) of PQAs. A dedicated Pfizer team has been regularly employing MAM on an in-house MAM platform to support biotherapeutic process and product development. In parallel, this team has continually explored and implemented improvements in the Pfizer MAM platform, including sample preparation and data processing automation, to move toward the next generation of MAM. Recently, a pre-commercial demo model of the new Thermo Scientific Orbitrap Exploris MX mass detector was evaluated in-house by the Pfizer MAM team. Here, the results of the evaluation and an assessment of the Orbitrap Exploris MX mass detector’s suitability as a next generation MAM instrument are presented. Learn: Pfizer MAM platform milestones for characterization and routine monitoring Automation of sample handling and data processing and reporting Evaluation and optimization of the Orbitrap Exploris MX mass detector for MAM REGISTER HERE
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Biopharmaceutical
Chromatography Data System Software
LC-MS
Mass Spectrometry
Webinar
1 attendees
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9 attendees
4
2
Characterization and sequence mapping of large RNA and mRNA therapeutics using mass spectrometry
Thursday, June 23, 2022
REGISTER HERE There is currently significant demand for the development of new and improved analytical methods for the characterization of mRNA therapeutics. The ability to rapidly identify, characterize and sequence map large mRNA therapeutics with high sequence coverage provides important information for identity testing, sequence validation and impurity analysis. In this live webinar, Mark J. Dickman, Ph.D., will present how an automated, high-throughput workflow for the rapid characterization and direct sequence mapping of large RNA and mRNA molecules enables routine comprehensive sequence coverage from a single analysis while overcoming challenges associated with digestion, oligonucleotide separation and identification. Attend this webinar to learn how to: Generate large sequence-specific oligonucleotide fragments Achieve high-resolution separation of complex mRNA digests Obtain confident identification of mRNA fragments Streamline data processing and sequence mapping REGISTER HERE
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(5)
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Biopharmaceutical
LC-MS
Mass Spectrometry
UHPLC
Webinar
9 attendees
4
2
Virtual Trivia Leaderboard
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