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No chromophore- no HPLC analysis?

Published on ‎02-21-2023 02:57 AM by Team TFS | Updated on ‎02-21-2023 07:42 AM

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Reversed phase column chromatography is commonplace in quality assessment of drugs. This usually involves the use of aqueous buffers, acetonitrile and/ or methanol as a mobile phase and commonly used UV detection. 

But what happens when excipients and drugs don't contain a chromophore?  These samples can't be identified and quantified by UV detection. Our answer is Charged Aerosol Detection (CAD), which is an excellent alternative and works as a universal detector for almost all non-volatile and many semi-volatile compounds.

Please join this webinar to hear about the work of our guest speaker, Ulrike Holzgrabe, from the department of Pharmaceutical and Medicinal Chemistry at University of Wuerzburg.  In her presentation, she will share her experience of using charged aerosol detection as an alternative in the quality assessment of drugs.

CAD has the flexibility and performance for analytical R&D, and the simplicity and reproducibility needed for manufacturing QA/QC and can be used for the analysis of pharmaceuticals in both large and small molecules. It is a reliable and an easy-to-use solution to quantify novel compounds without the need for compound specific calibration and is a key technology in our high throughput library purification platform.


Learn how CAD can be applied in your work with tips, tricks, pointers, and expert advice. 


Join our panel of experts for a roundtable and Q&A discussion 


With Special guest Ulrike Holzgrabe, Institut für Pharmazie und Lebensmittelchemie University of Wuerzburg and Paul Gamache, Director - Research and Development, Frank Steiner, Senior Manager- Product Applications & Scientific Advisor and Tibor Muellner, Senior Product Applications Specialist from Thermo Fisher Scientific.


We invite you to submit any questions you may wish to be discussed on this registration page.



Who should attend:

  • Laboratory managers and directors 
  • Technology leaders 
  • Principal scientists 
  • Laboratory analyst 

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Tue, Mar 21, 2023 05:00 AM PDT
Tue, Mar 21, 2023 06:00 AM PDT