The analysis of single-cell proteomes has recently become a viable complement to transcriptomics and genomics studies, as proteins are the main driver of cellular functionality and mRNA levels are often an unreliable proxy of such. Both multiplexed and label-free mass spectrometry-based approaches with single-cell resolution have attributed surprising heterogeneity to cell populations believed to be homogenous. Even though specialized experimental designs and instrumentation have demonstrated remarkable advances, the efficient sample preparation of single cells still lags behind.
In this live webinar, learn how Karl Mechtler has developed an end-to-end workflow to efficiently prepare and analyze samples for single-cell proteomics by mass spectrometry. A cellenONE® proteoCHIP sample preparation device, coupled to Thermo Scientific Orbitrap mass spectrometers, comprises a single-cell proteomics workflow solution with surprising sensitivity and throughput.
Attend this webinar to learn how to:
Identify key challenges and solutions for single-cell proteomics experiments
Understand an end-to-end workflow for single-cell proteomics sample preparation and analysis
Learn how mass spectrometry approaches can be applied to single-cell proteomics