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How HPLC-CAD Analysis Can Allow You to See Hidden Extractable Oligomers 18th Otober, 14:00 CEST

Published on ‎09-12-2023 01:37 AM by Team TFS | Updated on ‎09-12-2023 03:47 AM


How HPLC-CAD Analysis Can Allow You to See Hidden Extractable Oligomers

Join us for an informative webinar on 18th October at 14:00 CEST. where we'll unveil our innovative in-house method for studying Extractables and Leachables (E&L) substances in common medical and pharmaceutical-grade plastics. We'll dive into the analysis of nylon, polyurethane, and PVC (epoxidized soybean oil) oligomers, showcasing our approach that leverages multiple advanced detectors to analyze a wide range of analytes with diverse chemical properties.


Our method incorporates an ingenious inverse gradient technique, fine-tuned with an in-line mixer and optimized gradient delay times. We'll demonstrate the application of a previously published calculation to determine analyte behavior, classifying them as non-volatiles or semi-volatiles using CAD (Charged Aerosol Detection).


By attending, you'll discover how our approach minimizes inter-analyte response factor variation, enhancing quantitative accuracy and reducing uncertainty in setting analytical evaluation thresholds. Ultimately, our method is designed to meet crucial requirements in E&L studies, ensuring efficient and cost-effective protection against potentially harmful substances. Don't miss this opportunity to stay at the forefront of E&L research.




How HPLC-CAD Analysis Can Allow You to See Hidden Extractable Oligomers

Katherine Lovejoy - Thermo Fisher Scientific

Roundtable and Q and A discussion


Learning points:

  • Determine which analytes behave as non-volatiles with CAD and can therefore be accurately quantified using surrogate standards
  • Improve quantification accuracy and reduce response factor variation using an inverse gradient
  • Use an in-line mixer to combine the analytical and inverse gradients and improve response uniformity

Who should attend:

  • Laboratory managers and directors
  • Technology leaders 
  • Principal scientists 
  • Laboratory analyst 


Wed, Oct 18, 2023 05:00 AM PDT
Wed, Oct 18, 2023 06:00 AM PDT
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