Elucidating the effects of substrate availability on growth and utilization in pathogenic microbes
A sub-class of pathogenic microbes exhibit drastically increased biomass accumulation when supplemented with SCFAs. This phenomenon was probed via stable isotope resolved untargeted metabolomics leveraging Thermo Scientific™ Compound Discoverer™ software. Metabolites presenting fold changes as well as downstream isotopic enrichment from a 13C2 acetate substrate were used to inform on this unusual phenomenon and increase our understanding of the microbe's pathogenic mechanism.
- Understand how to study biological metabolism with liquid chromatography-mass spectrometry
- Learn how to perform untargeted stable isotope labeling experiments
- See advanced tools for analyzing and reporting untargeted stable isotope labeling data
Tue, May 17, 2022 08:00 AM PDT
Tue, May 17, 2022 09:00 AM PDT