Elucidating the effects of substrate availability on growth and utilization in pathogenic microbes w
Published on 04-21-202204:49 PM by
lmciccone| Updated on 05-17-202207:04 AM
A sub-class of pathogenic microbes exhibit drastically increased biomass accumulation when supplemented with SCFAs. This phenomenon was probed via stable isotope resolved untargeted metabolomics leveraging Thermo Scientific™ Compound Discoverer™ software. Metabolites presenting fold changes as well as downstream isotopic enrichment from a 13C2 acetate substrate were used to inform on this unusual phenomenon and increase our understanding of the microbe's pathogenic mechanism.
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