Your educational resource for the latest applications, information and research in sample preparation, chromatography, mass spectrometry, trace elemental analysis and laboratory data management.
Showing results for 
Search instead for 
Did you mean: 

Blog Articles

Going Underground for World Water Day 2022

The 2022 theme of World Water Day (March 22) is Groundwater - making the invisible, visible. Why is this important? It is estimated there is over a thousand times more water in the ground than on the ...

593 Views 0 Comments 2 Kudos

Don’t Get Lost in Your HPLC Method Development

HPLC method development is a bit like trying to solve a maze. The goal – the cheese, if you will – is to develop a method that provides adequate resolution, sensitivity, robustness and throughput. Sou...

2286 Views 0 Comments 2 Kudos

Next-Generation Low-Flow LC Technology is Not Marketing Buzz

What does it mean to be the next generation? You don’t have to look far to find the term “next-generation” or “NextGen” used to describe new technology. But what does it mean to describe a product or ...

28646 Views 0 Comments 1 Kudos

Signs You Need a New HPLC System (And How to Move Forward)

Like all great things in life, your treasured HPLC system will not last forever. If you identify with any of these issues, you should consider replacing your instrument. I used to joke in grad school ...

377 Views 0 Comments 0 Kudos

How Liquid Chromatography Benefits the Planet

PSA: Climate change is real!Melting glaciers and the extinction of polar bears. Dead coral reefs and acidification of the ocean. Increased droughts and raging wildfires. A warming ocean and stronger h...

411 Views 0 Comments 1 Kudos

Are You Missing Analytes in Your Liquid Chromatography?

I’m sure that is a question that many cannot answer. How do you know if you are missing analytes if you’ve never detected them previously? I am confident, though, that most would wish to have the conf...

479 Views 0 Comments 0 Kudos

The Role of HPLC in Metabolomics

Mass spectrometry-based metabolomics is frequently coupled to a diverse range of chromatographic techniques such as liquid chromatography (LC), ion chromatography (IC), and gas chromatography (GC).I r...

361 Views 0 Comments 0 Kudos

Why Your Lab Should Upgrade Its HPLC or UHPLC System

Making the switch isn’t always easy, but it’s worth the investment. I vividly remember the day in graduate school when my advisor asked me if I’d be “okay” giving up the HPLC instrument I used for two...

248 Views 0 Comments 1 Kudos

The What, Why, and How of Productivity in Your HPLC Lab

In the mid-1970s, the combination of industrial action by coal miners with the OAPEC oil embargo meant that the UK was running desperately short of fuel for electricity generation. As a result, the go...

213 Views 0 Comments 0 Kudos

The Finite Lab

We all accept that modern research life requires us to balance creativity with maximizing the return on investment of our instrumentation. In fact, both these demands continue to grow, and at a certai...

155 Views 0 Comments 0 Kudos


This almost sounds like a line from Shakespeare, but HPLC or high-performance liquid chromatography and ultra-high-performance liquid chromatography (UHPLC) came a little after the ‘Bard of Avon.’ Bot...

4009 Views 0 Comments 0 Kudos

How to Stop Your Mass Spectrometer Procrastination

If 10 years ago you told me I would be writing an article about avoiding procrastination I would have laughed as I thought I was a procrastinator myself. I have come to realise that it wasn’t ‘true’ p...

181 Views 0 Comments 0 Kudos

Five Additional Pharmaceutical Impurity Questions

Over the past two months, and during our recent pharmaceutical impurity workshop in Switzerland with LGC Standards, we’ve been asked some additional questions related to pharmaceutical impurities. In ...

499 Views 0 Comments 0 Kudos

What Is Dual LC and How Does It Benefit Me?

I think we can all generally agree that usually two is better than one: a bicycle is more efficient than a unicycle, two hands or minds are often better than one at completing tasks, etc. Does this tr...

535 Views 1 Comments 0 Kudos

Top Four Questions about Pharmaceutical Impurities

Over the past year, myself and Dr. Christian Zeine of LGC, have been engaging with scientists involved in the analysis of pharmaceutical impurities. During this time, there have been some questions th...

1339 Views 2 Comments 0 Kudos

Six Glycan Analysis Strategies for Biotherapeutics

Glycosylation is one of the most common protein post-translational modifications and can affect the protein’s functionality, stability and immunogenicity. It is for these reasons that for biopharmaceu...

228 Views 0 Comments 0 Kudos

Detector Technologies for (U)HPLC

When it comes to liquid chromatography there are numerous choices available for the detection of your analyte, but which of these offers the greatest sensitivity, is most suitable for your particular ...

769 Views 0 Comments 0 Kudos