HPLC method development is a bit like trying to solve a maze. The goal – the cheese, if you will – is to develop a method that provides adequate resolution, sensitivity, robustness and throughput. Sou...
Do you struggle to transfer validated HPLC methods between labs or different instruments? Is your business losing money or missing critical deadlines due to the struggle? You are not alone. Transferri...
Change is the only constant we have in life. And while we are living proof of Darwinism, we certainly were not prepared for the suddenly abrupt lifestyle changes COVID-19 threw our way. While there wa...
Our world today is anything but normal. In fact, leaders and futurists consider this world the “never normal,” in that everything will always be in flux and what is normal will constantly be redefined...
With so many HPLC detector options, how do you know which one is the right fit?An essential component of every chromatography instrument is the detector. You cannot see or measure the concentration of...
PSA: Climate change is real!Melting glaciers and the extinction of polar bears. Dead coral reefs and acidification of the ocean. Increased droughts and raging wildfires. A warming ocean and stronger h...
The word pressure is among scientific terms used in our daily life. At least once in life, you have pumped up a ball or balloon. Atmospheric pressure is a weather indicator, and as a car owner, you re...
I’m sure that is a question that many cannot answer. How do you know if you are missing analytes if you’ve never detected them previously? I am confident, though, that most would wish to have the conf...
Mass spectrometry-based metabolomics is frequently coupled to a diverse range of chromatographic techniques such as liquid chromatography (LC), ion chromatography (IC), and gas chromatography (GC).I r...
With one massive, global health concern on everyone’s mind these days, it’s easy to forget that other problems haven’t gone away and may even be just as important or becoming even more critical. They’...
Being completely confident that I have not undercooked my meat dishes (or made my dinner guests sick) has never been my forte. Not too long ago, I discovered a multi-use programmable pressure cooker. ...
The 48th International Symposium on High-Performance Liquid Phase Separation and Related Techniques, or HPLC 2019, concluded yesterday in Milan. It was a fascinating five days in the Italian sunshine,...
This summer sees two prominent five-year anniversaries taking place: in July 2014 the first Thermo Scientific™ Vanquish™ UHPLC system was launched, the Vanquish Horizon, and then in September 2014 I j...
Recently, I leased a new mid-sized SUV. Deciding to transition from a sedan to an SUV was a lengthy process as I evaluated how important the extra space was to me. Unfortunately, once I decided to com...
We all accept that modern research life requires us to balance creativity with maximizing the return on investment of our instrumentation. In fact, both these demands continue to grow, and at a certai...
This almost sounds like a line from Shakespeare, but HPLC or high-performance liquid chromatography and ultra-high-performance liquid chromatography (UHPLC) came a little after the ‘Bard of Avon.’ Bot...
Illicit drug use and addiction has become an unprecedented public health crisis. According to the CDC, more than 190 people die every day in the United States after overdosing on drugs, with two-third...
Worldwide, researchers are searching for ways to boost the immune system’s ability to fight cancer; one such way is by developing novel therapeutics within the pharmaceutical/biopharmaceutical industr...
Over the past two months, and during our recent pharmaceutical impurity workshop in Switzerland with LGC Standards, we’ve been asked some additional questions related to pharmaceutical impurities. In ...
I think we can all generally agree that usually two is better than one: a bicycle is more efficient than a unicycle, two hands or minds are often better than one at completing tasks, etc. Does this tr...
Pressure fluctuations or detector baseline drift may be reoccurring problems faced by an LC operator. In such a case, the first inclination may be to blame the LC system, mainly pump and detector, bec...
The one parameter in analytical liquid chromatography that has been consistently increasing has been the pump pressure of HPLC (high performance liquid chromatography) and UHPLC (ultra-high performanc...
You may read the title of this article and wonder how these two are connected as they seem about as far apart as you could possibly imagine. But there are more similarities than you think. And, I beli...
Liquid chromatography tandem mass spectrometry (LC-MS/MS) is fast emerging as the gold standard for accurate, fast and cost-efficient clinical analyses. However, its mainstream adoption by clinical la...
Which side of the line do you sit on? Let me break the ice: I sit on the chromatographer side. Most people sit firmly on either side of the line; not many consider themselves to be both. If you ask a ...
Over the past 10 years, liquid chromatography tandem mass spectrometry (LC-MC/MS) has evolved into a highly efficient and specific analytical method, suitable for a growing range of clinical applicati...
I’ve recently returned from HPLC 2017 in Prague where a number of different HPLC and UHPLC systems were showcased and discussed in the many excellent scientific presentations. To many, I am sure, ther...
Liquid chromatography is just liquid chromatography, right? Wrong. Liquid chromatography can come in many disguises, with analytical and preparative liquid chromatography (LC) being the most common. O...
Latin. in wine there is truth.By definition the “truth in wine” is that we are more likely to say and what we mean once a few glasses of wine have passed our lips. We may be more likely to say what we...
This year I have attended a number of conferences across a variety and routine and applied markets and whilst viewing the many posters at these events, something struck me; nearly all of them we focus...
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