There is a great deal of information in the public domain about the analysis of oligonucleotides by liquid chromatography-mass spectrometry (LC-MS). Its ability to measure multiple parameters, such as...
Have you ever seen pressure fluctuations or retention time shifts in your HPLC that go away as suddenly as they appeared? Do you use buffers in your HPLC application? If you answered yes, read this bl...
This month the European Medicines Agency (EMA) issued further revisions to the ever-changing guidance for drug producers when it comes to nitrosamine testing. In 2018 the Federal Drug Administration (...
Lunar New Year is an important holiday celebrated by many countries and communities worldwide. Also known as the Chinese New Year or Chinese Spring Festival, it will be celebrated on February 1 in 202...
Daily routine simplified While we all are different, most of us have very similar daily routines. We sleep at night, wake up in the morning, brush teeth, exercise, have breakfast, go to work, have lun...
The rise of mass-spectrometry in proteomics research Decades of significant advancements in mass-spectrometry technologies have resulted in better resolution, higher sensitivity and mass accuracy, sim...
For years, laboratory professionals gained knowledge through hands-on experience, personal interactions and discussions at forums, symposiums, workshops and seminars. Not much had changed since I emba...
It Takes Two to Tango Liquid chromatography mass spectrometry (LC-MS) is one of the most powerful and versatile tools available for quantitative and qualitative analysis. LC-MS users often divide them...
September 2021 saw the launch of a new low-flow UHPLC solution, the Thermo Scientific™ Vanquish™ Neo UHPLC system and Thermo Scientific™ PepMap™ Neo UHPLC columns. When we talk about HPLC columns, ter...
Curiosity is the primary driver of science. But developing natural curiosity into scientific thinking and motivation to uncover the endless wonders of nature is a difficult task. The Information Techn...
What does it mean to be the next generation? You don’t have to look far to find the term “next-generation” or “NextGen” used to describe new technology. But what does it mean to describe a product or ...
Once every now and again a topic hits the headlines in the analytical world so hard that within a year everybody is talking about the best way to solve the problem, and the best solutions to use. Ever...
What does it mean to go beyond, to exceed your goals? Some synonyms are to excel, outdo, surpass and transcend. These words mean “to go or be beyond a stated or implied limit, measure or degree.” Goin...
Could there be a substance more potent than morphine? Opioid epidemic is a phrase used routinely as of late. Psychoactive drugs are used medicinally for surgical anesthesia, palliative care and chroni...
Everyone needs a balanced diet to stay healthy. As an extreme example, professional athletes require a scientifically constructed diet to achieve peak performance, along with a scientifically designed...
Why is this the holy grail? We all know food samples are tricky. There are a lot of different matrices, analytes, contaminants and sample preparation methods to consider in food analysis, making this ...
Mass production makes it possible to bring thousands of gadgets to your home, kitchen and office. The application stores on your mobile devices have millions of products ranging from analyzing the sto...
Life is a beautiful continuity no matter what obstacles it throws at us, we keep going. Science keeps evolving and we find innovative solutions to everyday challenges through those smaller or larger s...
If we needed evidence that virus research is an important area to focus on, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and cumulative COVID-19 human health impact have p...
As 2020 draws to a close it is a good time to reflect on what has probably been the strangest year that most of us have ever experienced. The word ‘unprecedented’ has been worn out by overuse and the ...
The history of medical science is full of exciting technological advances. From antibiotics deemed “wonder drugs” in 1929 to the discovery of DNA’s double helix by James Watson and Francis Crick in 19...
With one massive, global health concern on everyone’s mind these days, it’s easy to forget that other problems haven’t gone away and may even be just as important or becoming even more critical. They’...
In Part 1 and Part 2 of this blog series, we touched upon ways ion chromatography (IC) can have more uses in the pharma lab than just for counterion analysis and how it offers a direct approach to pol...
There are a few Ranitidine (brand name Zantac among others) drug manufacturers getting heartburn over product recalls at the moment. This popular generic drug for the treatment of indigestion and refl...
It has been three years since I wrote on the subject or whether LC or LC-MS could ever replace immunoassays; this is the Analyte Guru article and a longer review published in the Journal of Bioanalysi...
With remarkable robustness the Thermo Scientific™ Orbitrap Exploris™ 480 mass spectrometer is an advanced, intelligence-driven instrument, built for ultimate performance and ease of use.Data certainty...
I would like to talk about fucose.‘Fucose…is that the red triangle1?’ is a question commonly asked by colleagues who are either advocates of the Oxford notation2 system, or less informed about the joy...
Recently my youngest daughter asked me, “Why do we have two eyes?”That was easy to answer, “To figure out the distance and size of objects more easily.” The next question was a bit more challenging: “...
Targeted quantitation workflows, used to screen against a predefined list of known analytes and accurately determine how much is present, play an essential role in safeguarding public health and prote...
Recently it seems the only question my fiancé and I receive is “How is wedding planning going?” Our sometimes not very enthusiastic answer then yields the question, “Have you considered a wedding plan...
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