Blog - AnalyteGuru

What Makes an HPLC Column?

September 2021 saw the launch of a new low-flow UHPLC solution, the Thermo Scientific™ Vanquish™ Neo UHPLC system and Thermo Scientific™ PepMap™ Neo UHPLC columns. When we talk about HPLC columns, ter...

Curiosity is Driving Technology and Vice Versa

Curiosity is the primary driver of science. But developing natural curiosity into scientific thinking and motivation to uncover the endless wonders of nature is a difficult task. The Information Techn...

Next-Generation Low-Flow LC Technology is Not Marketing Buzz

What does it mean to be the next generation? You don’t have to look far to find the term “next-generation” or “NextGen” used to describe new technology. But what does it mean to describe a product or ...

Every Tool You Will Ever Need for Nitrosamine Impurity Analysis

Once every now and again a topic hits the headlines in the analytical world so hard that within a year everybody is talking about the best way to solve the problem, and the best solutions to use. Ever...

Enabling Beyond Brilliant LC-MS Research

What does it mean to go beyond, to exceed your goals? Some synonyms are to excel, outdo, surpass and transcend. These words mean “to go or be beyond a stated or implied limit, measure or degree.” Goin...

Rising to the Challenge: Detecting One of the Deadliest Substances

Could there be a substance more potent than morphine? Opioid epidemic is a phrase used routinely as of late. Psychoactive drugs are used medicinally for surgical anesthesia, palliative care and chroni...

Are Your Cells on a Star Athlete Diet?

Everyone needs a balanced diet to stay healthy. As an extreme example, professional athletes require a scientifically constructed diet to achieve peak performance, along with a scientifically designed...

Automating Sample Preparation for Food Analysis – the Holy Grail!

Why is this the holy grail?We all know food samples are tricky. There are a lot of different matrices, analytes, contaminants and sample preparation methods to consider in food analysis, making this f...

One for All and All for One: Versatility Matters for NanoLC Systems

Mass production makes it possible to bring thousands of gadgets to your home, kitchen and office. The application stores on your mobile devices have millions of products ranging from analyzing the sto...

Leading the Way to Learning

Life is a beautiful continuity no matter what obstacles it throws at us, we keep going. Science keeps evolving and we find innovative solutions to everyday challenges through those smaller or larger s...

Integrative Structural Biology and Its Moment in the Spotlight

If we needed evidence that virus research is an important area to focus on, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and cumulative COVID-19 human health impact have p...

Virtual 2020

As 2020 draws to a close it is a good time to reflect on what has probably been the strangest year that most of us have ever experienced. The word ‘unprecedented’ has been worn out by overuse and the ...

Is the Multi-Attribute Method (MAM) the next big thing?

The history of medical science is full of exciting technological advances. From antibiotics deemed “wonder drugs” in 1929 to the discovery of DNA’s double helix by James Watson and Francis Crick in 19...

What are nitrosamines and why should I care?

With one massive, global health concern on everyone’s mind these days, it’s easy to forget that other problems haven’t gone away and may even be just as important or becoming even more critical. They’...

Challenging Pharmaceutical Impurity Analyses Part 3 – IC-MS Is the Newest Trick in the Book

In Part 1 and Part 2 of this blog series, we touched upon ways ion chromatography (IC) can have more uses in the pharma lab than just for counterion analysis and how it offers a direct approach to pol...

Why Is Orbitrap-Based MS So Good for Analyzing NDMA Impurities in Zantac?

There are a few Ranitidine (brand name Zantac among others) drug manufacturers getting heartburn over product recalls at the moment. This popular generic drug for the treatment of indigestion and refl...

Immunoassay or LC-MS?

It has been three years since I wrote on the subject or whether LC or LC-MS could ever replace immunoassays; this is the Analyte Guru article and a longer review published in the Journal of Bioanalysi...

Warning! Fucose Matters

I would like to talk about fucose.‘Fucose…is that the red triangle1?’ is a question commonly asked by colleagues who are either advocates of the Oxford notation2 system, or less informed about the joy...

See Better with More Than One Eye: UHPLC with Multi-Detector Approach for Comprehensive Sample Characterization

Recently my youngest daughter asked me, “Why do we have two eyes?”That was easy to answer, “To figure out the distance and size of objects more easily.”The next question was a bit more challenging: “A...

Purchasing the Right LCMS: Lessons Taken from Wedding Planning

Recently it seems the only question my fiancé and I receive is “How is wedding planning going?” Our sometimes not very enthusiastic answer then yields the question, “Have you considered a wedding plan...

Lessons as a New Homeowner

As a new homeowner I’m quickly becoming accustomed to the laundry list of To Dos around the house. While drywall and electrical work are new territory for me, there are so many parallels between home ...

The Trimmings You Don’t Want with Your Turkey

Especially over the holiday season, it is often taken for granted that consumers can go to their local supermarket and easily fill their baskets with a broad range of meat, poultry, fish and dairy pro...

A Toolbox for Biopharmaceuticals

As 2018 draws to a close, it’s been another exciting year in the area of biopharmaceuticals. We’ve seen further success from immunotherapy based approaches, new biopharmaceuticals have come to market ...

Building Immunity with the Right Tools

Worldwide, researchers are searching for ways to boost the immune system’s ability to fight cancer; one such way is by developing novel therapeutics within the pharmaceutical/biopharmaceutical industr...

Using Mass Spectrometry for Oligonucleotide and Peptide Synthesis Assessment

Synthetic oligonucleotides and peptides are frequently used in both research and medicinal applications today. Their synthesis is relatively straightforward, but they undergo quality control to confir...

Why Does the Monoclonal Antibody Make Such an Ideal Biotherapeutic?

If you review any charts of the top 10-20 selling drugs over the past decade you will quickly notice that drugs based on monoclonal antibodies are now overtaking their small molecule alternatives and ...

Five Additional Pharmaceutical Impurity Questions

Over the past two months, and during our recent pharmaceutical impurity workshop in Switzerland with LGC Standards, we’ve been asked some additional questions related to pharmaceutical impurities. In ...

Meeting the Biotin Challenge with Mass Spectrometry

Nowadays, people are using a lot of nutritional and dietary supplements. Influence from social media, high drug prices, and the burden of hectic lifestyles are compelling consumers to try supplements ...

Which Mass Spectrometer Is the Best?

If I had a dollar for every time someone asked me which mass spectrometer was the best or which one to buy in a particular situation, I could probably afford to buy a high-end mass spectrometry system...

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