Simplifying mRNA 5’ Cap Characterization
Why is the 5’ capping important? The 5’ cap of mRNA plays multiple key biological functions: regulation of nuclear export, prevention of degradation by exonucleases, and promotion of translation. To e...
Blog Articles
Thermo Fisher to Present End-to-End E&L Solutions at Extractables & Leachables USA
The Chromatography & Mass Spectrometry Division and the Clinical Research Business (which includes PPD® Laboratory services) of Thermo Fisher Scientific will host side-by-side booths and conference ta...
Are Your Cells on a Star Athlete Diet?
Everyone needs a balanced diet to stay healthy. As an extreme example, professional athletes require a scientifically constructed diet to achieve peak performance, along with a scientifically designed...
Overcoming the Challenges of Nitrosamine Analysis Using the Latest GC-MS Technology
With roughly 50% of the world population taking prescription drugs, it is important to ensure that pharmaceutical products are safe. Nitrosamine impurities have been widely publicized recently. A year...
Enabling Testing Laboratories to Provide High Quality, High Resolution Mass Spectrometry Results
In my last blog post “Re-defining Productivity for Small Molecule, High-resolution Mass Spectrometry Analysis”, I mentioned that Thermo Fisher Scientific recently launched the Thermo Scientific Orbitr...
Nine Ways to Advance BioPharma in 2020
It’s an exciting time in biopharmaceuticals. We are seeing success in immunotherapy-based approaches, new biopharmaceuticals have come to market, increasing approvals for the biosimilars, and an exhil...
Top 3 Scan Modes to Consider for Small Molecule Quantitation on an Orbitrap Mass Spectrometer
Almost a year ago, my blog post, “Purchasing the Right Mass Spectrometer: Triple Quadrupole vs. High-Resolution Accurate Mass Spectrometry” discussed differences to consider when evaluating triple qua...
5 More Reasons to Justify a New LCMS for Your Research Discoveries
In 2013, we changed the paradigm for how our customers were able to approach their research with the introduction of the first Thermo Scientific Orbitrap Tribrid Mass Spectrometer (MS). The Orbitrap T...
What makes the new Orbitrap Exploris 480 extraordinary simplified?
With remarkable robustness the Thermo Scientific™ Orbitrap Exploris™ 480 mass spectrometer is an advanced, intelligence-driven instrument, built for ultimate performance and ease of use.Data certainty...
Top Six Reasons Upgrading Your Small Molecule Structural Elucidation Approach May Be in Order
Whether the mass spectrometry-based approach you use today is tedious and time consuming, doesn’t deliver the confident results you need or you are running low on talent with technical competency, it ...
Don’t Be a Fool! Five Things to Consider When Selecting Your Next Research Mass Spectrometer for LFQ
The Pursuit Pursuit of high-throughput sample phenotyping through label-free quantitation (LFQ) using LC-MS requires substantial instrument performance to enable researchers to evaluate their experime...
Purchasing the Right Mass Spectrometer: Triple Quadrupole vs. High-Resolution Accurate Mass Spectrometry
In my last blog post, “Purchasing the Right LCMS: Lessons Learned from Wedding Planning” I encouraged you to think through a couple of key questions around your LCMS instrument purchasing goals. In to...
Making Characterizing Unknowns as Easy as Targeted Quantitation with Orbitrap Technologies
Targeted quantitation workflows, used to screen against a predefined list of known analytes and accurately determine how much is present, play an essential role in safeguarding public health and prote...
Purchasing the Right LCMS: Lessons Taken from Wedding Planning
Recently it seems the only question my fiancé and I receive is “How is wedding planning going?” Our sometimes not very enthusiastic answer then yields the question, “Have you considered a wedding plan...
Why is Orbitrap mass spectrometry so well suited to targeted screening and quantitation?
Targeted screening and quantitation workflows based on gas or liquid chromatography coupled with mass spectrometry (GC-MS or LC-MS) play a central role in the daily activities of analytical laboratori...
What makes Orbitrap mass spectrometry the first choice for both routine and research applications?
It’s been over a decade since the first single-stage benchtop Thermo Scientific Orbitrap mass analyzer was introduced: the Thermo Scientific Exactive Orbitrap mass spectrometer arrived on the scene ba...
Synthetic Urine, A Clean Catch?
With the opioid crisis raging and recreational marijuana use becoming legal in nine US states and the District of Colombia, the concerns about clean drug tests are on the rise. While urine remains the...
Meeting the Biotin Challenge with Mass Spectrometry
Nowadays, people are using a lot of nutritional and dietary supplements. Influence from social media, high drug prices, and the burden of hectic lifestyles are compelling consumers to try supplements ...
Six Glycan Analysis Strategies for Biotherapeutics
Glycosylation is one of the most common protein post-translational modifications and can affect the protein’s functionality, stability and immunogenicity. It is for these reasons that for biopharmaceu...
When Should You Walk on the Path to More Confident Quantitation?
Who uses a taxi anymore? Boy, was I surprised when I heard these ridesharing apps are not used by everyone these days. Recently, I successfully transitioned a good friend from a taxi service to a well...
The Backstretch of Equine Drug Testing
The impact of drugs in the environment is an emerging problem, but not just for forensic or public health agencies. This issue has also entered the paddocks of horse racing. Failed equine drug tests h...
PEDs and the Olympics: The Allure of SARMs
Since the inception of the modern Olympics more than 100 years ago, athletes have engaged in various activities in order to gain a competitive edge—from alcohol to amphetamines to anabolic steroids. B...
ASMS 2017 – Day 4 – The Performance Gap Just Got Wider
This year, we’re excited to announce at ASMS 2017 the GC Orbitrap technology that is raising the bar even further in the world of HRAM GC-MS with new technology and tools for the Q Exactive GC and Exa...
What’s Old Is New, What’s New Is Unknown: The Evolution of Plant-Based Drugs
What do chemists and goats have in common? They both played a part in discovering plant-based psychoactive drugs. Drugs such as cathinone, mitragynine, cocaine, and morphine were originally ingested b...
Gear Up for Tomorrow’s Quantitation
Quantitation is changing as new discoveries are made. Are you prepared to tackle the future challenges in Quantitation? Traditional quantitation was fueled by the knowledge of what compounds and/or co...
Itching to Learn About Allergens?
Food allergen testing has progressed. Melanie Downs, Ph.D. Assistant Professor of the Food Allergy Research & Resource Program within the Department of Food Science & Technology, University of Nebrask...
Interview with an Expert: Lukasz Rajski from EURL-FV Discusses Pesticide Analysis Utilizing HRAM Orbitrap Technology
Łukasz Rajski works in EURL-FV, an EU reference lab, while finalizing his Ph.D. thesis. His focus is pesticide analysis of fruits and vegetables using high resolution accurate mass spectrometry (HRAM)...
An Interview with Dr. Rochat on the Benefits of Quantitative Orbitrap HRAM Mass Spectrometry
Dr. Bertrand Rochat is convinced of quantitative Orbitrap HRAM mass spectrometer for clinical research and targeted and non-targeted metabolomics. He has been on the front line of the absolute quantif...
Food Fraudsters- Catch Us if You Can!
This is the challenge for analytical chemists: to detect food fraud and stop fraudsters cheating consumers and ignoring food safety considerations by substituting a high-value product with a lower-val...
Synthetic Drugs: The Case for a More Effective War on Drugs
Traditional law enforcement forensic testing can’t identify and ban new synthetic compounds fast enough. Traditional techniques, such as immunoassay, require lengthy development time for new test kits...
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