Simplifying mRNA 5’ Cap Characterization
Why is the 5’ capping important? The 5’ cap of mRNA plays multiple key biological functions: regulation of nuclear export, prevention of degradation by exonucleases, and promotion of translation. To e...
Why is the 5’ capping important? The 5’ cap of mRNA plays multiple key biological functions: regulation of nuclear export, prevention of degradation by exonucleases, and promotion of translation. To e...
The Chromatography & Mass Spectrometry Division and the Clinical Research Business (which includes PPD® Laboratory services) of Thermo Fisher Scientific will host side-by-side booths and conference ta...
Everyone needs a balanced diet to stay healthy. As an extreme example, professional athletes require a scientifically constructed diet to achieve peak performance, along with a scientifically designed...
With roughly 50% of the world population taking prescription drugs, it is important to ensure that pharmaceutical products are safe. Nitrosamine impurities have been widely publicized recently. A year...
In my last blog post “Re-defining Productivity for Small Molecule, High-resolution Mass Spectrometry Analysis”, I mentioned that Thermo Fisher Scientific recently launched the Thermo Scientific Orbitr...
It’s an exciting time in biopharmaceuticals. We are seeing success in immunotherapy-based approaches, new biopharmaceuticals have come to market, increasing approvals for the biosimilars, and an exhil...
Almost a year ago, my blog post, “Purchasing the Right Mass Spectrometer: Triple Quadrupole vs. High-Resolution Accurate Mass Spectrometry” discussed differences to consider when evaluating triple qua...
In 2013, we changed the paradigm for how our customers were able to approach their research with the introduction of the first Thermo Scientific Orbitrap Tribrid Mass Spectrometer (MS). The Orbitrap T...
With remarkable robustness the Thermo Scientific™ Orbitrap Exploris™ 480 mass spectrometer is an advanced, intelligence-driven instrument, built for ultimate performance and ease of use.Data certainty...
Whether the mass spectrometry-based approach you use today is tedious and time consuming, doesn’t deliver the confident results you need or you are running low on talent with technical competency, it ...
The Pursuit Pursuit of high-throughput sample phenotyping through label-free quantitation (LFQ) using LC-MS requires substantial instrument performance to enable researchers to evaluate their experime...
In my last blog post, “Purchasing the Right LCMS: Lessons Learned from Wedding Planning” I encouraged you to think through a couple of key questions around your LCMS instrument purchasing goals. In to...
Targeted quantitation workflows, used to screen against a predefined list of known analytes and accurately determine how much is present, play an essential role in safeguarding public health and prote...
Recently it seems the only question my fiancé and I receive is “How is wedding planning going?” Our sometimes not very enthusiastic answer then yields the question, “Have you considered a wedding plan...
Targeted screening and quantitation workflows based on gas or liquid chromatography coupled with mass spectrometry (GC-MS or LC-MS) play a central role in the daily activities of analytical laboratori...
It’s been over a decade since the first single-stage benchtop Thermo Scientific Orbitrap mass analyzer was introduced: the Thermo Scientific Exactive Orbitrap mass spectrometer arrived on the scene ba...
With the opioid crisis raging and recreational marijuana use becoming legal in nine US states and the District of Colombia, the concerns about clean drug tests are on the rise. While urine remains the...
Nowadays, people are using a lot of nutritional and dietary supplements. Influence from social media, high drug prices, and the burden of hectic lifestyles are compelling consumers to try supplements ...
Glycosylation is one of the most common protein post-translational modifications and can affect the protein’s functionality, stability and immunogenicity. It is for these reasons that for biopharmaceu...
Who uses a taxi anymore? Boy, was I surprised when I heard these ridesharing apps are not used by everyone these days. Recently, I successfully transitioned a good friend from a taxi service to a well...
The impact of drugs in the environment is an emerging problem, but not just for forensic or public health agencies. This issue has also entered the paddocks of horse racing. Failed equine drug tests h...
Since the inception of the modern Olympics more than 100 years ago, athletes have engaged in various activities in order to gain a competitive edge—from alcohol to amphetamines to anabolic steroids. B...
This year, we’re excited to announce at ASMS 2017 the GC Orbitrap technology that is raising the bar even further in the world of HRAM GC-MS with new technology and tools for the Q Exactive GC and Exa...
What do chemists and goats have in common? They both played a part in discovering plant-based psychoactive drugs. Drugs such as cathinone, mitragynine, cocaine, and morphine were originally ingested b...
Quantitation is changing as new discoveries are made. Are you prepared to tackle the future challenges in Quantitation? Traditional quantitation was fueled by the knowledge of what compounds and/or co...
Food allergen testing has progressed. Melanie Downs, Ph.D. Assistant Professor of the Food Allergy Research & Resource Program within the Department of Food Science & Technology, University of Nebrask...
Łukasz Rajski works in EURL-FV, an EU reference lab, while finalizing his Ph.D. thesis. His focus is pesticide analysis of fruits and vegetables using high resolution accurate mass spectrometry (HRAM)...
Dr. Bertrand Rochat is convinced of quantitative Orbitrap HRAM mass spectrometer for clinical research and targeted and non-targeted metabolomics. He has been on the front line of the absolute quantif...
This is the challenge for analytical chemists: to detect food fraud and stop fraudsters cheating consumers and ignoring food safety considerations by substituting a high-value product with a lower-val...
Traditional law enforcement forensic testing can’t identify and ban new synthetic compounds fast enough. Traditional techniques, such as immunoassay, require lengthy development time for new test kits...