10 Pharma New Year’s Resolutions You Can Keep
It’s that time of year again. The presents were wrapped and then unwrapped, the Christmas tree is a shadow of its former self, we drank, we ate, we loved, we relaxed and we’re now wearing our stretchy...
Blog Articles
How to Choose a Mass Spec for BioPharma
It’s always enjoyable and interesting when speaking to BioPharma customers about how they decide on which mass spectrometric (MS) platform to select. In fact, it seldom seems to be one single platform...
AAPS 2016 and the Future of Hope
The American Association of Pharmaceutical Scientists saw over 6500 attendees and 400 exhibitors attend their annual meeting and exposition at the Colorado Convention Center, Denver. This event starte...
It’s In The Bag. Literally.
When you produce a biopharmaceutical you grow living cells that are engineered to express (produce) a therapeutic protein drug. These cells grow in BIG plastic bags. Very big. Sometimes several thousa...
Is Your Analytical Method Keeping Pace with Biopharmaceutical Development?
The bioanalysis of large molecules has continued to grow in significance with the increase in development of proteins as therapeutic agents. In particular, the development of monoclonal antibody thera...
BioPharMoore: Unravelling Biopharmaceutical Protein Digestion
Early in the development stages of any protein therapeutic, a peptide mapping experiment is undertaken. A peptide map involves breaking the macromolecular protein structure down into its constituent p...
Finding HOPE Using Peptide Mapping?
On a rainy winter’s day in Boston, MA, we took a journey in biotherapeutic peptide mapping with Guilong Charles Cheng of Alexion Pharmaceuticals, Inc. Join us on this journey and discover how advancem...
How to Stand Out from the Biopharmaceutical CMO Crowd
It was 22nd February 2016 at 8 am. The sun was shining and the sprinklers were quenching the thirst of the surrounding vegetation as we pulled into the parking lot. We had arrived at Ajinomoto Althea,...
Challenging the Status Quo at HPLC 2016
We’ve expanded our family of Thermo Scientific Vanquish UHPLC systems! HPLC 2016 marks the birth date of the Vanquish Flex Binary UHPLC System, bringing high throughput and high pressure gradients to ...
BioPharMoore: Getting Personal with Biomarker Research
Whilst in Boston in February this year to speak with customers about their peptide mapping workflows, I found myself at the Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center.BRIMming ...
ASMS 2016 – Day 4 – What I Gained from ASMS 2016
It’s that time of year again, when those of us who are mad about our mass spec may have had the chance to get together to share and discuss how we are collectively weighing the world!The American Soci...
Vlogging #BioPharma to Death
BioPharMadnessSome days I feel like I am going mad. Maybe I am? On the wall in my sister’s restaurant is a quote from Alice in Wonderland:"Have I gone mad?""I'm afraid so. You're entirely bonkers. But...
Education is Important, Getting the Right Answers is Importanter …
Okay. I will start by admitting that this all began with a trip to the toilet. In my local pub.I was busy chatting with friends about work and exactly what it is that I do, my industry does and how it...
Admiring the Architecture of the Building Blocks of Life
After almost a decade of studying and analysing proteins I’ve often found myself trying to explain to people “Why proteins?” What’s all the fuss about?I recently came across this video produced for th...
The Government, Easter Eggs & Biotherapeutics: A Glycosidic Link
With the UK government debating the introduction of a tax on sugar, recent Easter celebrations with two young children in the house and the burgeoning biotherapeutic market, I’ve got sugar on my mind....
Why Do Some Drug Trials Kill?
The Modern Pharmaceutical Machine Modern pharmaceuticals have a huge impact on the health and well-being of patients and their caregivers by slowing or preventing disease, alleviating symptoms, and in...
5 Drug Development Dilemmas to Avoid
Bioanalytical labs are integral to clinical and pre-clinical drug development. From assay validation, analysis and sample tracking to reporting of results, the requirements are demanding. Couple this ...
How Close Are You to Achieving Your Lab Potential?
We’ve just returned from an exciting trip spreading the laboratory informatics word to companies eager to learn how Laboratory Information Management Systems (LIMS) and other software can help their b...
Biopharmaceutical Production in Your Garden Shed
This evening I was waiting at the airport to catch a flight home and a dangerous thing happened; I started to think. I was thinking whether I could set myself up as a therapeutic antibody supplier, as...
Pittcon 2016 – Day 3 – Adventures in Biopharma
It’s another beautiful day here in Atlanta and the Thermo Fisher Scientific booth (#2239) is bustling! Today, my fellow scientists and I were talking about how exciting it is to be a part of the world...
Why Have High Performance When You Can Have Ultra-High Performance?
Liquid chromatography plays an extremely important part in the development and production of biotherapeutic drugs. From separation of large quantities of antibodies in cell culture media to minute qua...
Danger! Unexploded Antibody!
I’ve always been fascinated by the field of immunology and the immune system, probably explaining why I took a doctorate in immunology. Two areas that particularly interest me are how the immune syste...
Crop Compost from Deceased Humans & Heavy Metal Toxicity
I recently read about the fascinating urban death project (linked to the project website) which converts deceased humans into crop compost to reduce burial costs, solve the problem of overcrowded ceme...
Antibodies Attack! What Happens When Biotherapeutics Go Bad?
It’s well known that biotherapeutic drugs (also known as biologics) are more difficult to produce consistently than our old friends, small molecule drugs. And, manufacturers spend untold amounts of mo...
Fifteen Minutes of FAME: Analysis of Fatty Acids
No, I am not looking for my place in the spotlights, nor do I want to compete in the X-factor TV show. For all you folks wanting to read about how to become famous, you can stop right now. Chromatogra...
Antibodies: Tough Killers or Big Softies?
Quick question: what is a monoclonal antibody? What does it really do? If you already work in biotherapeutics, or if your high-school biology is within memory then you may know. But for the rest of us...
Are you Implementing SEND (Standard for Exchange of Nonclinical Data)?
With collaboration between sponsors and Contract Research Organizations (CROs) becoming ever more common, the standardization of nonclinical data between sponsors and regulatory bodies is, in turn, be...
Pharma Blockbuster League: Biopharmaceuticals 7 – Small Molecules 3
In 2013, seven out of the top ten drugs by revenue were biopharmaceuticals rather than traditional small-molecule, chemically synthesized, drugs. What’s more the top three drugs were all biologics and...
Your Elemental Analysis is Costing You More Than You Think: Part 3
In the final post to my three-part blog series on trace elemental analysis, I want to discuss the importance of proper sample preparation. In my previous blog posts (see links to posts at end of this ...
Your Elemental Analysis is Costing you More Than you Think: Part 2
In the second part to my three-part series on trace elemental analysis, I want to address automated, intelligent liquid dilution that can provide two benefits, namely, a reduction in costs and a speed...
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