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Your educational resource for the latest applications, information and research in sample preparation, chromatography, mass spectrometry, trace elemental analysis and laboratory data management.
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Blog Articles

5 Ways to Become a Biopharma MAM Master

More Than MonitoringThe Multi-Attribute Method (MAM) for structural confirmation of protein therapeutics involves a targeted search of peptide mapping data using advanced, GMP compliance-ready softwar...

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TOF vs. Orbitrap

Choosing the Right Instrument For Intact Protein Structural InsightsThe analysis of intact proteins, such as therapeutic monoclonal antibodies (mAbs) under ‘native’ (non-denaturing) conditions using m...

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A Toolbox for Biopharmaceuticals

As 2018 draws to a close, it’s been another exciting year in the area of biopharmaceuticals. We’ve seen further success from immunotherapy based approaches, new biopharmaceuticals have come to market ...

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Salt or pH Gradient for Intact Protein Separations?

For the first 18 years of my life I had little understanding of gradients. I grew up in one of the flattest parts of the UK. In fact, it was so flat that for driving tests everyone used the same road ...

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Bispecifics: Killing Two Birds with One Stone…

I never did like the expression: “killing two birds with one stone.” Why would anyone want to kill a bird, let alone two!? I do like the idea of achieving two purposes with a single action, though, es...

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Current and Future Biopharmaceuticals

Over the past two decades there has been a decisive shift towards large molecule, biological drugs or biopharmaceuticals, and away from traditional chemically synthesised, small molecule drugs. The re...

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Danger! Unexploded Antibody!

I’ve always been fascinated by the field of immunology and the immune system, probably explaining why I took a doctorate in immunology. Two areas that particularly interest me are how the immune syste...

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Antibodies: Tough Killers or Big Softies?

Quick question: what is a monoclonal antibody? What does it really do? If you already work in biotherapeutics, or if your high-school biology is within memory then you may know. But for the rest of us...

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Why I Turned from Phosphorylation to Glycan Analysis

Most of my early research career focused on the post-translational modifications (PTMs) of proteins and in those days there was only one worthy PTM in my eyes and that was phosphorylation while glycos...

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