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Aaron_TFS
Team TFS
Team TFS

E&L Cropped.jpg

 

 

AnalyteGuru continues its Networking in Science webinar series with Paulina Pinedo-Gonzalez, Ph.D., from SGS, Fairfield, New Jersey, on May 11 at 10 a.m. CDT. In this webinar, Dr. Pinedo-Gonzalez will present the strategies SGS employs to identify unknown extractables and leachables (E&L) in pharmaceuticals.

 

Click here to register now

 

Extractables and leachables overview

 

Accurate identification of extractable and leachable (E&L) compounds is vital to ensure there are no potentially harmful chemicals being absorbed into a finished drug product or medical device when it is manufactured, packaged, or stored. Identifying trace levels of unknown E&L compounds in matrices — sometimes relatively complex — is a challenging task.

 

Looking for additional information about E&L analysis? Check out our blog post, Thermo Fisher to Present End-to-End E&L Solutions at Extractables & Leachables USA.

 

Additionally, if you are looking for resources on E&L impurities, explore our E&L Information webpage.

 

Why is it important to test for E&L compounds?

 

Accurate identification of E&L compounds is vital to ensure that products we consume or use are safe. It also safeguards that there are no potentially harmful chemicals being absorbed into a finished drug product, medical device, or food contact material when it is manufactured, packaged or stored.

 

What approach does SGS take to analyze E&Ls

 

High-resolution mass spectrometers (HRMS) that enable an accurate mass determination, such as the Thermo Scientific™ Orbitrap™ LC-MS, generate high-quality data that can often lead to the identification of an empirical formula and narrows down the class of compound of the unknown. Based on this information, the identity of an unknown is further evaluated following a systematic approach.

 

Dr. Pinedo-Gonzalez will share strategies that demonstrate practical steps to follow for structural elucidation of unknown non-volatile and semi-volatile organic compounds based on their LC-MS spectra. This stepwise approach in structure identification has proven useful for the effective identification and quantification of E&L compounds in a variety of pharmaceutical and medical products.

 

What are the key learning objectives of this webinar?

 

  • Practical tips to identify semi-volatile and non-volatile E&Ls from pharmaceutical and medical products by LC-MS
  • The importance of high-resolution mass spectrometry in the inference of a molecular formula for an unknown ion
  • Advantages of incorporating MS/MS information for the structure elucidation of unknown compounds

 

Don’t miss out on this webinar. Click here to register now.

 

Do you have a question for one of our E&L experts now? Click here to submit your question.

Speak to a specialist now

 

Meet the presenter

 

Paulina-headshoot Lower res 2.jpgPaulina Pinedo-Gonzalez, Ph.D.
E&L Chemist II
SGS Health Science

 

 

Dr. Pinedo-Gonzalez is an E&L chemist at SGS Health Science in Fairfield, NJ. At SGS she focuses on E&L testing of pharmaceutical containers and medical devices by GC-MS/FID and LC-MS/PDA. Prior to joining SGS, she was a postdoctoral research associate at Columbia University, working on high-resolution mass spectrometry applications mainly for the environmental field.

 

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13 Comments
Lori_TFS
Team TFS
Team TFS

Looking forward to learning more about extractable and leachable space from SGS. Thanks for sharing!

sebastienmorin
Team TFS
Team TFS

This will be a great webinar. I look forward to learning more about E&L analysis from SGS. 

RobertRoss
Team TFS
Team TFS

Look forward to it!

Aaron_TFS
Team TFS
Team TFS

Thanks Robert, Lori, Seb! Me too! 

Dujuan
Involved Contributor
Involved Contributor

Looking forward to this webinar! 

Aaron_TFS
Team TFS
Team TFS

@Dujuan Thanks for registering! I'm looking forward to Paulina's talk and seeing what SGS's capabilities are for E&L analysis. 

lixuepu
Team TFS
Team TFS

Great!!! Looking forward to this webinar.

Aaron_TFS
Team TFS
Team TFS

Thanks @lixuepu

paul-dewsbury
Team TFS
Team TFS

I read about their work on the SGS Health Science LinkedIn site here so looking forward to hear Paulina speak about the topic

Chongming
Involved Contributor
Involved Contributor

Looking forward to the webinar soon!

Molly_I2
Community Manager
Community Manager

@Chongming , @Dujuan - Feel welcome to ask questions in the forum if any arise! We are grateful to have you join!

Link to conversation here: Ask a Question after the event about ID'ing unknown extractable & leachables or thank our speaker! 

jingli-hu
Team TFS
Team TFS

Great talk. How can we access the recorded webinar?

Dujuan
Involved Contributor
Involved Contributor

Great job on the presentation, Paulina!