The use of high resolution accurate mass spectrometry (HRAM) is a well-established technique, mainly for its utility in the determination of unknown contaminants. A recent publication by Leon Barron from King’s College in London discusses the use of HRAM for pharmaceuticals in wastewater (link to Science Direct article).
What makes Orbitrap technology amazing compared to other examples of HRAM is its ability to quantify as well as confirm unknowns. There are additional examples in the literature demonstrating the Orbitrap technology’s ability to qualify and quantify using its scan mode flexibility. A relatively recent publication by Ganna Fedorova demonstrates an excellent comparison of the identification and quantification of illicit drugs in wastewater (link to article) between triple quad mass spectrometers and Orbitrap mass spectrometers. Quantitation of pesticides (link to application note PDF), including low detection limits and reproducibility, has also been shown for pesticides and wastewater.
In order to facilitate the identification and quantification of unknown compounds in environmental and food samples, we have developed a unique library with over 1600 compounds. This library (link to Sepctral Libraries product page) contains 5 to 6 HRAM MS/MS spectra per compound. I invite you to explore more about our amazing Orbitrap technology, and I look forward to hearing what you discover.
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