Are you looking for a better way to monitor product quality? This blog post explains a must-have technique that can help you meet your quality standards every time.
Quality control is an essential aspect of every manufacturing process. As a manufacturer, you should establish process controls to ensure your final products meet quality and safety standards set by regulatory agencies.
One of the best tools you can use for manufacturing quality control is high-performance liquid chromatography (HPLC). This application is pivotal for ensuring the safety and efficacy of pharmaceuticals, food products, cosmetics, and other manufactured goods.
Here are the top seven benefits of using HPLC for manufacturing quality control.
1. Ensures lot-to-lot product purity and consistency
One key benefit of HPLC is the high level of accuracy and precision across individual runs. HPLC instruments can separate and even detect trace amounts of impurities and degradants in your raw materials and finished goods, which makes it an ideal tool for monitoring variability across different production batches. Monitoring the purity of new incoming materials and finished goods can help you prevent quality issues before your products hit the market.
2. Efficiency for large-scale production
HPLC is a highly efficient analytical technique capable of analyzing multiple samples in a short amount of time. Maximizing your productivity is particularly important in large-scale manufacturing when you need to analyze thousands of samples quickly and efficiently. Even better, you can automate your HPLC methods, which allows for high-throughput analysis and lower costs associated with quality control.
3. Sensitivity for monitoring product degradation and shelf-life
HPLC is sensitive and capable of identifying trace levels of compounds, from nanogram up to picogram amounts, in your products. This aspect is essential for pharmaceutical manufacturing, where even minute amounts of impurities can impact product safety and efficacy. You can also use HPLC to monitor and quantify degradation products, which can help establish product stability and shelf-life.
4. Selectivity for purifying structurally similar compounds
HPLC is a selective technique, which means you can use this technique to separate and purify structurally related compounds like isomers in a complex mixture. This feature is useful when your products contain enantiomers that you need to separate and purify before packaging.
5. Allows versatility for contract manufacturing organizations
Thanks to different column chemistries, you can use HPLC to analyze a variety of compounds, including polar and nonpolar compounds, acidic and basic compounds, and large and small molecules. This versatility makes HPLC an ideal tool for quality control in contract manufacturing, where you often make a range of products like small molecules, proteins and antibodies.
6. Meets regulatory compliance for on-market products
Adhering to regulatory compliance is critical in many manufacturing industries. HPLC is a widely accepted quality control tool in manufacturing and is often required by regulatory agencies, such as the FDA. By using HPLC for quality control, you can ensure your products maintain safety and efficacy as mandated by regulators.
7. Lowers your operating costs
While the initial investment in HPLC equipment and training may be significant, the long-term cost savings to your business are substantial. By accurately detecting product quality issues, HPLC can help you avoid costly product recalls and protect your brand reputation. Additionally, HPLC can reduce the costs and time associated with manual testing, leading to significant savings over time.
Discover our top HPLC solutions to supplement your manufacturing
As you can see, HPLC is essential for ensuring product purity, quality, and stability. By using HPLC for quality control, you can meet strict regulatory requirements and ultimately make products safe and effective for all consumers.
Want to learn more about our HPLC solutions for your manufacturing? Discover how you can unlock better quality control processes with the Thermo Scientific Vanquish Duo UHPLC Systems.