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Have you ever thought of your kitchen as a lab?

Team TFS
Team TFS

lab-2Who doesn’t love homemade cookies?

I’ve heard it a million times: “It makes sense that you like to bake. You’re a chemist, and you like to follow recipes.”

I can tell you that I have a lot of chemistry friends who cannot bake to save their lives, but as it turns out, I am one of those stereotypical chemists who loves precisely measuring out all of my ingredients to create amazing breads, cookies, and cakes. I’m also great at multi-tasking and at time management in the kitchen, just like in the lab, to get my baking done quickly.

During the holidays I really get into baking, making multiple varieties of cookies. And, I am usually on a time crunch, since I promise to bring cookie trays to parties I forget about.

Since I only have one oven in my kitchen, I really need to make sure I utilize every minute to get all of my cookies done in time. I prep the first batch of cookies, pop them in the oven, and immediately work on the next batch of cookies.

Why do I get started on the next batch of cookies right away? To save time.
If I have my second batch of cookies ready to go, I can pop them in the oven as soon as the first batch is done! If I were to wait around for the first batch of cookies to finish before starting my second, my oven would sit there empty doing nothing.

Now this is where the kitchen is like the lab: I have one oven, just like I might have one mass spec in the lab, that I want to be up and running and collecting data as much as possible. And just like my kitchen, I want to save time and finish faster without compromise.

What’s the problem? If I have one LC or LC-MS setup with a gradient method, you typically have a wash and re-equilibration step. This usually means that your detector or mass spec is idle during the wash and re-equilibration step (just like the oven in my kitchen that’s waiting for me to finish the next batch of cookies to pop in), reducing your overall throughput.

Ever wish you could keep your detector or mass spec collecting data during these steps?

Good news!
You can do just that and improve your lab’s throughput and get the most out of your detector or mass spectrometer using the Thermo Scientific™ Vanquish™ Duo UHPLC for Tandem LC or LC-MS by:

  • Increasing sample throughput without modifying a validated method

  • Improving return on investment by maximizing the instrument utilization

  • Reducing column carry over through extended column washing without sacrificing throughput

  • Simplifying method setup with automatic method conversion from your original gradient method


How does the Vanquish Duo for Tandem LC or LC-MS do this?

The Vanquish Duo for Tandem LC or LC-MS system maximizes downtime associated with column reconditioning by running your analyses on two pumps and two columns all on one system. Deliver the analytical gradient on the first pump and first column; while the second pump reconditions the other column—preparing for the next injection. This configuration allows you to use two identical columns to run your sequence faster without compromising data quality or modifying a validated method.

Things to know about the Vanquish Duo system for Tandem LC or LC-MS:

  1. Choose two identical columns from our diverse portfolio of HPLC and UHPLC Columns, including our Vanquish validated UHPLC columns, and run them side-by-side in order to implement this workflow in your lab.

  1. There are 1000 and 1500 bar options for maximum flexibility.
    Build the system with a single autosampler and either the new Thermo Scientific™ Vanquish™ Dual Pump F (up to 1000 bar, two independent ternary-solvent blending flow streams in one housing) or two single Thermo Scientific™ Vanquish™ Binary Pump H (up to 1500 bar)/ Thermo Scientific™ Vanquish™ Binary Pump F (up to 1000 bar).

  1. Choose a combination of detectors from our diverse HPLC and UHPLC Detector portfolio.
    Depending on your application needs, you can use any combination of our detectors, which include our mass spectrometers, optical detectors and charged aerosol detectors, to detect the analytes of interest.

  2. Its easy-to-use with tools built into the Thermo Scientific™ Chromeleon Chromatography Data Systems (CDS) Software.
    If you already have a method that’s been validated and tested, you can quickly convert this to a tandem LC method using guided wizards on Chromeleon CDS – no additional work!

  1. Save money and time in the long run.
    Depending on your application needs, when you consider the total cost of ownership (instrument, solvent, columns, maintenance costs, etc.) to run a tandem LC or LC-MS set up compared to a single channel LC you generally save time and money in the long run.
    Use our new HPLC System Total Cost of Ownership Calculator to help you determine your potential cost savings.

So don’t forget that your kitchen is your lab and there are ways to save time without any compromises.  Happy baking!

Check out this application note on tandem UHPLC operation for high-throughput LC-MS peptide mapping analyses.

Learn more about Thermo Fisher Scientific’s solution for Tandem LC or LC-MS visit

How much can you save with a Tandem LC setup? Use our new calculator to figure it out. Click here >