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andreas-huhmer
Team TFS
Team TFS

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ASMS 2021 is fully underway in Philadelphia, PA and once again we are excited to be empowering scientists to drive groundbreaking discoveries with the introduction of new-generation mass spectrometry instruments, workflows and software. Here are some of the highlights you can expect from the week ahead:

 

Mass spectrometer streamlines biopharmaceutical development and quality control (QC)

The Thermo Scientific Orbitrap Exploris MX mass detector allows biopharmaceutical laboratories to easily implement multi-attribute method (MAM), and perform intact  analysis of monoclonal antibodies, oligonucleotide mass determination and peptide mapping. To simplify the transition of biotherapeutics from development to manufacturing, the new system enables QC customers to use the same method established earlier in a molecule's journey to commercialization, accelerating the biopharmaceutical pipeline. Laboratories can also benefit from reduced downtime and maintenance, as well as seamless method transfers. The new system offers superior data quality and high-confidence results, even for users with limited mass spectrometric experience.

 

Updated MAM workflow bridges the gap between development and manufacturing

The Thermo Scientific MAM 2.0 workflow streamlines biopharmaceutical characterization, process monitoring and release testing by replacing multiple traditional assays with one comprehensive analysis, delivering insights on multiple critical product quality attributes. MAM 2.0 includes the training, ongoing support and partnership required for laboratories to enhance their analytical workflows across R&D, manufacturing and QC environments. To remove the bottlenecks often seen by organizations moving therapeutics from development to manufacturing, the new workflow enables the use of the same platform throughout the entire process, ultimately creating an end-to-end solution allowing for the seamless transfer of data and knowledge across teams and departments.

 

Advanced software leverages new technology to enhance data acquisition and analysis

For proteomic researchers, the combination of Thermo Scientific Proteome Discoverer 3.0 software with CHIMERYS by MSAID will greatly increase their ability to identify peptides and proteins, allowing for a wider and deeper understanding of biological systems. By leveraging artificial intelligence (AI) to reimagine the analysis of tandem mass spectra, peptide coverage and quantitation capabilities are increased, unlocking exciting new possibilities for proteomics researchers.

To provide scientists performing small molecule analysis in metabolomics, environmental, food safety, clinical and forensics laboratories with faster and more sensitive compound detection, the Thermo Scientific Compound Discoverer 3.3 software offers an enhanced peak detection algorithm and improved peak quality rating.

The Thermo Scientific BioPharma Finder 5.0 software creates new capabilities for biotherapeutic workflows by increasing analytical throughput and confidence through built for purpose data processing, curation and customizable reporting. The secure environment enables global collaboration and can be used across multiple application workflows, such as peptide mapping analysis, oligonucleotide analysis, intact mass analysis and top-down analysis.

Finally, the Thermo Scientific LipidSearch 5.0 software now supports direct infusion workflows and features an extensive database of 1.5 million lipids, enabling real-time monitoring in addition to more accurate lipid quantitation.

To learn more about Thermo Fisher Scientific’s presence at ASMS, visit www.thermofisher.com/ASMS