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Community Activity

Welcome to Our Food Webinar Tour # 1

Would you like to know how the experts interpret the new pesticide residue standard?Would you like to know how our solutions can help you follow these standards?Then stay tuned, see you on 8/17 !

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Remen by Team TFS
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VOC analysis with purge and trap

For EPA methods such as 8260 and 524.2 purge and trap is used with GC-MS. Here is a simplified explanation of how the technique works. Does any one have other resources they use when describing this technique?

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NaOH vs KOH

When you buy a new CarboPac column it always comes with a Quality Assurance Report (QAR). So we can always test the columns following the procedure in the QAR to see if the column still meets the specifications. However sometimes the QAR is conducted...

SeanA by Involved Contributor
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carbon neutralization webinar

Opportunities and challenges for the development of environmental monitoring industry under carbon neutralization webinar, welcome to click the link below to sign up.https://hyt.ibisaas.com/home/meeting/index.html?group_id=1&aid=1366&sales_id=404&ref...

ICP-MS system

When is triple quadrupole ICP-MS the best tool for laboratories in applied & analytical sciences? Where are you faced with challenges when requiring reduced detection limits , larger sample loads and expecting greater confidence in data quality from ...

RukaYue by Team TFS
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metabolomics of TCM meeting

Hi everybody,we are going to hold a webinar for TCM metabolomics of Aug 10th. Welcome you sign up now! Pls scan the below QR code. Thanks!

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shenping by Involved Contributor
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How do YOU do Ionic Polar Pesticides in Food?

Interested in discovering how you can effectively look at those pesky polar pesticides? IC-MS/MS methodology is a way to constantly provide you with quality data with long-term productivity. This is very important to our Food Safety, especially if yo...

Early Single Cell Proteomic References?

Are you aware of early single cell proteomics publications before 2017, that is done on potentially large single cells, like xenopus oocytes? Looking to find & share the pioneering research that was likely not identified as "single cell proteomics or...

Did you attend the 2021 Global IC Symposium

The 2021 Global IC Symposium was live over three days in June. What was your favorite session or biggest takeaway? If you were unable to make it, you can still attend on-demand by clicking here and let us know your thoughts.

Meet the Team

Welcome to the Community! My name is Samana and I am part of the Moderator Team. My goal is to help foster a space of productivity and positivity. If you have any questions about content, posts or simply getting started, please do not hesitate to rea...

Signs You Need Need a New HPLC System

It's a sad fact, but your HPLC instrument won't live forever. Check out my newest blog about signs you need a new HPLC system. https://www.analyteguru.com/t5/Blog/Signs-You-Need-a-New-HPLC-System-And-How-to-Move-Forward/ba-p/13044

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Resolved! Liquid Chromatography Method Transfer Guide

Every liquid chromatographer should have a go-to resource with technical and instrument solutions to overcome method transfers issues. Download your FREE HPLC method transfer guide now! https://assets.thermofisher.com/TFS-Assets/CMD/brochures/eb-7381...

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Meet the Team

Hello. I’m George S. I edit and publish the AnalyteGuru blog, an educational resource for the latest applications, information and research in sample preparation, chromatography, mass spectrometry, trace elemental analysis and laboratory data managem...

GeorgeTFS by Community Manager
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Meet the Team

Role Description The Community Manager provides the overall direction and helps evolve the community by launching new initiatives and functionalities. Community Moderators help ensure that all community members feel welcome in the community and get q...

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Siri_TFS by Moderator
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AnalyteGuru Community Guidelines

Everything we do starts with you. Our goal is to foster a safe environment for you and your peers to network, ask questions, and offer solutions within the global scientific community. Let us make this a valuable experience for everyone by following ...

Molly_I2 by Community Manager
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What will I find on the AnalyteGuru blog?

The AnalyteGuru blog is your educational resource for the latest applications, information and research in sample preparation, chromatography, mass spectrometry, trace elemental analysis and laboratory data management. Since 2012 the purpose of the b...

GeorgeTFS by Community Manager
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What are Scientific Communities?

Scientific Communities are forums where you can find conversations focused on specific industries – e.g., pharma/biopharma, environmental, food & beverage; or those centered around specific techniques – e.g., mass spectrometry or liquid chromatograph...

GeorgeTFS by Community Manager
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What is a knowledgebase?

A knowledgebase (also called a tribal knowledgebase) is a collection of articles that captures and organizes helpful community information. Knowledgebases are great community resources for several reasons: You can search for knowledgebase articles or...

GeorgeTFS by Community Manager
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Orbitrap IQ-X

Designed for Small-Molecule Analysis The Thermo Scientific™ Orbitrap IQ-X™ Tribrid™ mass spectrometer is designed to reveal complex chemical structures for compound identification and small molecule analysis. The system combines industry-leading mass...

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with possible signal intensity fluctuation under specific acquisition conditions.

Orbitrap Tribrid Series 3.4 PatchThe fluctuation in signal intensity could be observed when performing DDA acquisition with precursor ions fragmented by resonance CID activation and with MS2 spectra acquired in Orbitrap and using Auto Mass Range sett...

Hello world!

Welcome to WordPress. This is your first post. Edit or delete it, then start writing!

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Sample Page

This is an example page. It's different from a blog post because it will stay in one place and will show up in your site navigation (in most themes). Most people start with an About page that introduces them to potential site visitors. It might say s...

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Sample Page

This is an example page. It's different from a blog post because it will stay in one place and will show up in your site navigation (in most themes). Most people start with an About page that introduces them to potential site visitors. It might say s...

test by Involved Contributor
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Stephen Jackson - 2021-03-15 16:21:03

I would like the ability to process GC NCI data in addition to PCI. It would even be helpful to just be able to merge features even if all the other nodes weren't NCI compatible. Maybe there's a work-around that I'm not aware of?Also, I would really ...

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Lukas Roth - 2021-03-15 05:24:06

I’m trying to run an analysis after making a few modifications to my workflow. However, when trying to execute the analysis the error below pops. I’ve tried shutting down Compound Discoverer and reprogramming the workflow, but the error still pops up...

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Ethan Roberts - 2021-03-11 22:15:07

To whom it may concern:Is each table/tab handled independently in the reporting software, or is there a way to link and/or pull information from another table into a different subreport?For instance- I wish to tie FISh coverage value from the Structu...

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A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling

Michelle L Dubuke1 , Sitara Chauhan1 , Sarah Trusiak1 , and Emily I. Chen1APPLICATION NOTE 65952To demonstrate the reliability and robustness of the Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer for large-scale, untargeted plasma protei...

Griet Jacobs - 2021-03-05 08:45:05

Hi,Is it possible to combine two scripting nodes?For us it would be very helpful if we have in the compound table (m/z; O/C and the H/C) values!2 times processing takes a lot of time...How can I do this?thank you,GrietAUTHOR: Griet JacobsAUTHOR EMAIL...

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Griet Jacobs - 2021-03-04 08:57:24

Dear,Yesterday I followed the webinar; new features in CD3.2 and there was mentioned that you are able to import .msp files in the library (fe lipidblast). I've update CD3.2 successfully and I want to add this library. Unfortunately, I can not choose...

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Pier-Luc Plante - 2021-03-02 19:57:50

I think that having a button accessible from the main interface that quickly adds/removes the Checked filter would be really appreciated. The Checked filter is something I use a lot (I suppose a lot a other users use it too). I am constantly filterin...

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Daniel Malheiro - 2021-02-16 08:28:24

We get an Execution error during step (5) "Error: database disk image is malformed". Do you happen to know how this is caused? and if there is a way to avoid it?AUTHOR: Daniel MalheiroAUTHOR EMAIL: dbam@msomics.comAUTHOR URL: SUBJECT: MyCompoundDisco...

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Orbitrap Tribrid Series 3.4 Patch: This patch works around a problem in which split peaks could be observed only after instrument bootup.

Orbitrap Tribrid Series 3.4 PatchAfter toggling instrument polarity or eFT state, or perhaps running the eFT calibration, the peak splitting goes away and does not return until the next instrument reset. This was traced to a problem with certain stag...

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue where sometimes the Trap Resonance CID calibration doesn’t reliably pass.

Orbitrap Tribrid Series 3.4 PatchIn some instances, the coarse calibration adjustment, that is automatically done behind the scenes, could make the calibration more difficult to pass, while the calibration would pass fine if this coarse adjustment wa...

Weijia - 2021-02-12 20:36:25

I’m trying to use Compound Discoverer.3.1.1.12 to process my LCMS data, and in the Workflows section I noticed that there are a bunch of “Current Workflow Issues” saying like “the processing node XXX is not known by this system”. And in the "Workflow...

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Eric Gier - 2021-02-11 18:39:25

Hello I am trying to increase the font size in the mass spectrum window so I can read the m/z values and the axes but I can't figure out how to do that. Any help is greatly appreciated!AUTHOR: Eric GierAUTHOR EMAIL: ericgier4@gmail.comAUTHOR URL: SUB...

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Liang zheng - 2021-02-03 13:52:34

Dear office, I want to ask the issues about results by CD3.2. I acquired the data by data independent analysis. Can you suggest if or not CD can analyze DIA data? Thanks.AUTHOR: Liang zhengAUTHOR EMAIL: tommy_0_mouse@hotmail.comAUTHOR URL: SUBJECT: M...

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Liang zheng - 2021-02-03 13:43:59

Dear office, I want to ask the issues about results by CD3.2 . I found that the results tables have many many ions form source fragmentations. They will give many false positive metabolites. How can we get rid of these source fragmentations ions.AUTH...

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Barnabas David - 2021-01-28 14:01:05

1. I have recorded an MS/MS spectra in the tune window of chromeleon then generated raw file. Can I analyse it in the Compound Discoverer the same way as chromatograms?2. If I click the View the Start page and Job Queue are active and the others (Chr...

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Chris Pook - 2021-01-06 06:30:09

I would love to see CD implement Retention Time prediction to compliment spectral matching for assigning IDs. I know that's quite a big ask so I would settle for some sort of retention time calibration based on abundant human metabolites.AUTHOR: Chri...

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Chris Pook - 2021-01-06 06:15:11

Hi, I can't get mzVault searches to work with either DDA or DIA data. I have exported the 2020 NIST library to .msp format and then imported this into mzVault. It looks fine. I have added it to the libraries in CD and turned off all the filters I can...

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Julie-anne FENGER - 2021-01-05 13:32:54

Hello,We installed CD3.2 on a new station, it is still under the trial version.I don't manage to connect it to mzcloud. Is there something that we should do ?I was not present when it was installed on the first licenced work station. I don't find inf...

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Zhang Guo - 2021-01-05 08:07:01

Hello, we would like to know how to export the column of background information when using Compound Discover software to export data in Excel?After several times of scrolling through the data, we found that only the column of background could not be ...

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Zhang Guo - 2021-01-05 07:59:21

Hello, we would like to know how to export the column of background information when using Compound Discover software to export data in Excel?After several times of scrolling through the data, we found that only the column of background could not be ...

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Dmitry Korzhenevskiy - 2020-12-30 09:35:18

My CompoundDiscoverer 3.0 (License # S1L8-71L2-06TC-VZ8U) fails Communication test with ChemSpider at step 4. Help please. Below is the copy of the test log.---------------------------------------------------------------------------------------------...

test by Involved Contributor
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Russell Williams - 2020-12-23 21:22:11

some compounds receive the name designation "similar to XXXXXXXX" and have a mass that differs from the compound XXXXXXXXwhat is the basis for this? Are they identified as "similar to" based on similar fragmentation pattern?AUTHOR: Russell WilliamsAU...

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Tal - 2020-12-23 11:06:54

Hi All,I have 8 files trying to process with 2 similar workflows (workflows files attached). In the first Workflow - Untargeted Metabolomics with Statistics Detect Unknowns with ID using Online and Local Databases and mzLogic. The process finishes fi...

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Tal - 2020-12-20 16:37:33

Dear all,I'd like to ask you to please add an example of adding a new table using the Scripting node.(like example #3 in the tutorial. but creating the new columns to a new table say Features New)I did try it by myself but the new table is not linked...

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Malgorzata Cebo - 2020-12-17 15:05:30

Dear Sir or Madam,I have a problem with a workflow for my new data set. I have samples with different cell numbers. I would like to apply scaling according to the number of cells. I try to do so by using a 'numerical factor' in the 'study definition'...

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Malgorzata Cebo - 2020-12-16 10:55:25

Dear Sir or Madam,I am a very new user of Compound Discoverer and I would like to ask a question about adding a scaling factor.I do metabolomics studies in cells, but I do not know the cell number in my samples prior to extraction and LCMS analysis. ...

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Multi-pathway signaling analysis using a synthetic phosphopeptide panel, standardized sample preparation kits and SureQuant internal standard targeted quantitation

Aaron S. Gajadhar1, Bhavin Patel2, Penny Jensen2, Sebastien Gallien3,4, Romain Huguet1, Kay Opperman2, John C Rogers2, Andreas Huhmer1, Daniel Lopez-Ferrer1 International Hupo 2020To develop a universal phosphopeptide enrichment and internal standard...

Extending Capabilities of Real-Time Database Search on the Orbitrap Eclipse Tribrid Mass Spectrometer for Multiplexed Proteomics

Yang Liu, William D. Barshop, Amirmansoor Hakimi, Jesse D. Canterbury, Romain Huguet, Rosa Viner International Hupo 2020To evaluate recent improvements to Real-Time Search for TMT SPS MS3 quantitation workflow including: 1) Close-out to prevent acqui...

Aishwarya Pandey - 2020-12-14 09:05:17

While processing the data using untargeted screening for full MS data, most of the times we get some predicted chemical formula which are not feasible for example:CHO9P, CH4O9. Can you kindly let us know what is the reason for such formula prediction...

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Leon - 2020-12-11 04:54:49

Hello, Thank your for reading this comments. I am a researcher using the CD3.1 . I recently found that polarity switching mode samples have problems. Phenylalanine, for exmple, they have more abudant ions in postive mode than negative (X10 Fold highe...

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Compound Discoverer 3.2 released

Compound Discoverer 3.2 has been released. New features include: Processing capability for GC-Orbitrap data Neutral loss searches Custom tags for annotating and filtering result table entries Support for importing structures from SDF files Support fo...

Tal - 2020-12-08 14:33:13

I made a scripting node that adds columns to the ChemSpider Result table and it works fine.I tried to create a new scripting node that instead of adding columns to the existing table ChemSpider Resultcreate a new table called "ChemSpider Results with...

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Tal - 2020-12-03 15:58:55

hello, We register the node as a standalone Scripting node that works fine base on the file "Installing the Simple Test node as an example Scripting node in Compound Discoverer 3.1." - section 4We want to add another one the same way but for some rea...

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Boryana Petrova - 2020-12-01 14:36:01

Hello, I am new to CD and trying to figure things out as much as possible on my own but I ran into some issues I cant solve. 1. usually when I acquire data (on Thermo's QE) I have three to four parallel scans: +/- mode FullScan, - mode with narrower ...

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Oleg Bondarev - 2020-11-24 19:29:47

Hi folks,By accident I did corrupted reporting template files.Could you help me?Thank you,Oleg BondarevAUTHOR: Oleg BondarevAUTHOR EMAIL: OlegBondarev@eurofinsUS.comAUTHOR URL: SUBJECT: MyCompoundDiscoverer - SupportIP: 75.130.14.90Array( [1_Name] =>...

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Zachary Laughrey - 2020-11-23 15:38:58

Got these errors and am not sure what they mean:5:59 PM (59): Search mzCloud Error Error: This implementation is not part of the Windows Platform FIPS validated cryptographic algorithms.6:12 PM (81): Apply mzLogic Error Error: This implementation is ...

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Alex Kovach - 2020-11-19 21:23:46

Hello,I very much enjoyed the discussion today from Tim Stratton, I thought it was very informative about the capabilities of Compound Discover and mzVault. We are working on developing a Compound Discover workflow to analyze a large quantity of comp...

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Dongting Liu - 2020-11-12 14:20:30

Hello, CD experts!My name is Dongting and I am a metabolite ID scientist at Q2 Solutions. CD has been very helpful to my recent work on searching for low level metabolites from bile, urine, plasma and feces. It is a very well designed software!! The ...

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Virtual Software Workshops

https://event.on24.com/eventRegistration/EventLobbyServlet?target=reg20.jsp&partnerref=fieldrep&eventid=2804612&sessionid=1&key=7F4C037924684A678D87FE9A1ADA3A5F®Tag=1779657&V2=false&sourcepage=register Data to knowledge with extensive Mass spectral l...

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Remo Badertscher - 2020-10-15 06:45:07

Hi,I used the "MetID w Stats Expected w Background Removal" workflow. In the resulting "Expected Compounds" table I found two compounds with the same Formula and MW. So far nothing confusing. But if I then have a look at how these compounds got built...

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Peter Jakab - 2020-10-13 07:33:01

Dear Support Team,I am Peter Jakab from Unicam Hungary Ltd (Official Hungarian Thermo Fisher distributor). One of our customer would use Compound Discoverer in pharma area. This is the reason why i would like to ask your kind help some Compound Disco...

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Chris Brueck - 2020-10-01 21:52:35

Having issues creating standalone node for all scripts except for "Simple Test". Could you please provide node.json files for each script?AUTHOR: Chris BrueckAUTHOR EMAIL: bru@jhu.eduAUTHOR URL: SUBJECT: MyCompoundDiscoverer - SupportIP: 68.84.8.56Ar...

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Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Husey...

Luis Peña - 2020-09-22 15:45:28

Good day. I have a recent problem with Compound Discoverer 3.2, none of my files are opening and upon startup there is an error "Failure to establish service connection" or "An unhandled exception has occurred". The only important change done to the ...

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Ellen Grant - 2020-09-15 19:41:01

Please respond and let me know who "owns" this site. Thanks. EllenAUTHOR: Ellen GrantAUTHOR EMAIL: ellen.grant@thermofisher.comAUTHOR URL: SUBJECT: MyCompoundDiscoverer - SupportIP: 73.211.67.124Array( [1_Name] => Ellen Grant [2_Email] => ellen.grant...

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Lindi Grabmann - 2020-09-14 08:08:26

Dear CD Team,I wanted to run a workflow today including the mzVault node when I realized that my spectral library database was corrupt. I still can add spectra though without any error meassage but it is e.g. not possible to export the database. Than...

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Dasheng Lu - 2020-09-05 08:19:47

If possible, I'd like the CD should have the following functions. 1)Just like in mzCloud, the CFI (characteristic fragmention ion) similarity searching should be available in Spectral libraries. 2) Just the function of isotopic pattern recognization,...

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Michael James - 2020-08-28 18:07:35

Hello,While using metabolomics workflows in compound discoverer 3.0.0.294, I'm getting the ChemSpider error below with 0 structures retrieved:ChemSpider retrieve results had errors: Thermo.Metabolism.Services.Web.AutoRetryLimitExceededException:Abort...

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Milinda Samaraweera - 2020-08-25 16:02:19

Hi, I'm trying to search a custom CID spectrum in massfrontier (text file with m/z and intensities). Not sure whether this is possible in MassFrontier.AUTHOR: Milinda SamaraweeraAUTHOR EMAIL: milinda.samaraweera@vranalytical.comAUTHOR URL: SUBJECT: M...

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Instrument Application Programming Interface

You can use the instrument control software to collect high-quality mass spectrometry data on the Thermo Scientific mass spectrometers. Control of the instruments is through two application packages: Tune and Method Editor. For questions about the so...

Shubham Kaushik - 2020-08-09 04:34:56

Dear Sir/MadamI am using COmpound discoveror 2.1 for analysis.From last 2 days I have found errors in Chemspider search node. Which is :Chemspider retrieve results had error: Thermo metabolism Service webAutoretry limit exceeded: Aborted web sequest ...

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Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry

Lennart Schnirch, Michal Nadler-Holly, Siang-Wun Siao, Christian K. Frese, Rosa Viner, and Fan LiuIn cross-linking mass spectrometry (XL-MS), the depth and sensitivity of cross-link detection is often limited by the low abundance of cross-links compa...

André Macherius - 2020-08-07 11:59:56

To whom it may concern,We recently updated our Compound Discoverer version from 3.0 to 3.1 and 3.1 SP1, respectively, and encountered a problem with the “Search mzVault” node we are not able to solve.When implementing the “Search mzVault” node in a w...

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Matthew Keller - 2020-07-31 19:35:39

I'd like to be able to export the compound annotations with metabolite identifiers (InChIKey/SMILES) as well as the common names. That would make it much easier to analyze later (many metabolites have multiple common names).AUTHOR: Matthew KellerAUTH...

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Julio Cesar España - 2020-07-31 01:35:22

Hello CD team, Everytime I try to excecute a simple analysis (making use of mzcloud and chemspider nodes) the Result is completed with two type of errors. Even when ONLY the FDA UNI - NML database selected as suggested in https://mycompounddiscoverer...

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Caroline Lewis - 2020-07-28 14:26:24

I am trying to view blanks and QC samples in the PCA plot, but under the "file" filter they are toggled on. They are showing up as 0/1, and when I hover over that file I get the message "0 out 1 item(s) shown, item(s) filtered out elsewhere". Is it p...

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XML Method Modification Interface

You can use the instrument control software to collect high-quality mass spectrometry data on the Thermo Scientific mass spectrometers. Control of the instruments is through two application packages: Tune and Method Editor. For questions about the so...

Alex Yoon - 2020-07-17 23:17:09

Hello, I am having an issue with "Map to KEGG Pathways" node. I get a Load Failures error, saying " The processing node "(n/a) MAP to KEGG Pathways" is not known by the system." It would be great if I can use this function for my study. Could you ple...

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Muhammad Usman - 2020-07-12 13:52:25

Sehr geehrter Herr Dr. Tautenhahn,ich versuche momentan ihre Scripting Nodes in meine Workflows einzubauen und habe bisher immer Erfolg gehabt, aber leider funktioniert das logP Scripting Node bei mir nicht. Eventuell können Sie mir bei der Behebung ...

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Rosalia Lopez Ruiz - 2020-06-25 11:13:37

Chemspider database failed. Communication test failed: --------------------------------------------------------------------------------------------------------------------------------------------6/25/2020 1:11:17 PMChemSpider: Checking service availa...

test by Involved Contributor
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Peter Walter - 2020-06-23 14:14:12

My computer was recently upgraded from Windows 7 to Windows 10 during which they wiped the drive. So I'm trying to reinstall CD but it will not activate. I installed CD 3.1 from flexnet. I entered the Product ID from the originalCD box (it was 2.0 or...

test by Involved Contributor
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An Ultra High-throughput Plasma Protein Profiling (uHTPPP) Workflow Using a Modified Quadrupole-Orbitrap Mass Spectrometer

Michelle L. Dubuke1, Sarah Trusiak1, Sitara Chauhan1,Ryan D. Bomgarden2, Sergei Snovida2, Bhavin Patel2, Emily I. Chen1.An automated plasma protein profiling workflow on the new Orbitrap Exploris 240 mass spectrometer can deliver the consistency, sen...

Detecting Stable Isotope Labeled Metabolites in Untargeted Analysis Using a Benchtop Orbitrap Mass Spectrometer and a Single Processing Software Platform

Amanda Souza, Ioanna Ntai, Tatjana Talamantes and Ralf TautenhahnPurpose: Develop an integrated mass spectrometry-based workflow for stable isotope labeling (SIL) in untargeted metabolomics covering data acquisition and analysis in a single experimen...

Sensitive and High-throughput Single-cell Proteomics Workflow on New Quadrupole-ion trap-Orbitrap Mass Spectrometer with FAIMS Separation

Khatereh Motamedchaboki1; Maowei Dou1; Yongzheng Cong2; Romain Huguet1; Aaron M Robitaille1; David M Horn1; Yufeng Shen3; Daniel Lopez-Ferrer1; Ryan T Kelly2, 4; Ying Zhu4.ASMS 2020Traditionally, proteomics experiments are applied to large population...

Turnkey, Multi-pathway Signaling Analysis Using a Synthetic Phosphopeptide Panel, Standardized Sample Preparation Kits and SureQuant Internal Standard Targeted Quantitation

Aaron S. Gajadhar1; Bhavin Patel2; Penny Jensen2; Sebastien Gallien3,4; Romain Huguet1; Kay Opperman2; John C Rogers2; Andreas Huhmer1; Daniel Lopez-Ferrer1 ASMS 2020Purpose: We sought to develop a universal phosphopeptide enrichment and internal sta...

Pushing the Limits of Sensitivity: Micropillar Array-Based Chromatography Coupled to a Quadrupole Orbitrap Mass Spectrometer and FAIMS for Low-Input Proteomics

Julia Kraegenbring1, Karel Stejskal2, Claudia Ctortecka2, Gabriela Krššáková2, Jeff Op De Beeck3, Tabiwang N. Arrey1, Bernard Delanghe1, Alexander Harder1, Karl Mechtler4ASMS 20201 Thermo Fisher Scientific, Hanna-Kunath-Str. 11, Bremen, Germany. 2 In...

Deep Proteome Coverage and Label-Free Proteomic Analysis of Low Numbers of Mammalian Cells with a Quadrupole-Ion trap-Orbitrap Mass Spectrometer

Min Huang, Xiujie Sun, and Yue ZhouASMS 2020Purpose: To improve the proteome coverage and label-free quantitation performance of limited number of mammalian cells. Methods: Different sample preparation methods and LC-MS parameters were compared for p...

Bas van de Velde - 2020-06-17 12:49:12

Dear Sir, Madam,My supervisor at KWR used compound discoverer (CD) to make a volcano plot of a water sample before and after ozonation. I am trying to recreate this using R. Now I saw that CD used Tukey HSD test after an ANOVA test. However I don't u...

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Climate Change Research

We believe that studying our past climate helps us understand climate change, and provides clues that help us plan for the future. https://bit.ly/2MXjbt2

Flavio Cinato - 2020-06-09 14:19:03

In the "Lists & Libraries" page, in the "Expected Compounds" Tab we need to add a compound which is a quaternary ammonium salt. When we import the structure (with or without positive charge on the nitrogen), the "Save" button is greyed out.Is there a...

test by Involved Contributor
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